Eucalyptol Protects against Cisplatin-Induced Liver Injury in Rats

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dc.authoridAkcakavak, Gokhan/0000-0001-5949-4752
dc.authoridKazak, Filiz/0000-0002-9065-394X
dc.contributor.authorAkcakavak, Gokhan
dc.contributor.authorKazak, Filiz
dc.contributor.authorDeveci, Mehmet Zeki Yilmaz
dc.date.accessioned2024-09-18T20:19:55Z
dc.date.available2024-09-18T20:19:55Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractEucalyptol (1,8-cineole), a terpenoid oxide, is known as the main component of eucalyptus essential oils. The antimicrobial, anti-inflammatory and antioxidant activities of eucalyptol have been reported in many studies. We investigated the possible effects of eucalyptol (EUC) against hepatotoxicity induced by cisplatin (CIS) in Wistar albino rats. A total of 24 rats were divided into 4 equal groups; Control (C), Eucalyptol (EUC), Cisplatin (CIS), and Cisplatin + Eucalyptol (CIS + EUC). CIS and CIS + EUC groups received cisplatin (12 mg/kg, in a single dose, intraperitoneally (i.p.)). EUC and CIS + EUC groups were treated with eucalyptol (100 mg/kg, seven days, orally). The rats were euthanised under appropriate conditions, and samples were taken. Histopathologically, hepatocyte degeneration and necrosis, sinusoidal dilatation, inflammatory cell infiltration and bile duct proliferation were significantly irregular in the CIS group compared to the C group. However, EUC treatment modulated changes in group CIS. Biochemically, EUC (100 mg/kg) treatment reduced oxidative stress against increased liver hepatotoxicity by decreasing MDA levels and increasing Glutathione (GSH), Glucose-6-phosphate dehydrogenase (G6PD) and Catalase (CAT) levels. EUC treatment down-regulated 8-hydroxy-2-deoxyguanosine (8-OHdG) levels, resulting in reductions DNA damage. It also significantly down-regulated inducible nitric oxide synthase (iNOS) expression. In conclusion, eucalyptol exerts protective effects on cisplatin-induced experimental liver toxicity in rats by improving oxidative stress and oxidative DNA damage and iNOS expressions.en_US
dc.identifier.doi10.1134/S106235902360085X
dc.identifier.endpage994en_US
dc.identifier.issn1062-3590
dc.identifier.issn1608-3059
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85167661099en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage987en_US
dc.identifier.urihttps://doi.org/10.1134/S106235902360085X
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9946
dc.identifier.volume50en_US
dc.identifier.wosWOS:001047181300018en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPleiades Publishing Incen_US
dc.relation.ispartofBiology Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecteucalyptolen_US
dc.subjectcisplatinen_US
dc.subjecthistopathologyen_US
dc.subjecthepatotoxicityen_US
dc.titleEucalyptol Protects against Cisplatin-Induced Liver Injury in Ratsen_US
dc.typeArticleen_US

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