Effect of propolis in the treatment of experimental Staphylococcus aureus keratitis in rabbits

Basit Öğe Kaydı
dc.authoridCETIN, Mustafa/0000-0003-4512-1124
dc.contributor.authorOksuz, H
dc.contributor.authorDuran, N
dc.contributor.authorTamer, C
dc.contributor.authorCetin, M
dc.contributor.authorSilici, S
dc.date.accessioned2024-09-18T20:55:29Z
dc.date.available2024-09-18T20:55:29Z
dc.date.issued2005
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose: The aim of this study was to investigate the antimicrobial and anti-inflammatory properties of an ethanolic extract of propolis, a natural resin produced by honeybees, and to determine synergistic activity between ciprofloxacin and propolis in the treatment of experimental Staphylococcus aureus keratitis. Methods: Sixteen young New Zealand white rabbits were given intrastromal injections of S. aureus strains. Twenty-four hours later, the rabbits were randomly divided into 4 groups: group 1 was treated with topical 0.3% ciprofloxacin drops along with the ethanolic extract of propolis drops; group 2 received topical 0.3% ciprofloxacin drops; group 3 was administered the ethanolic extract of propolis drops, and group 4, the control group, was treated with phosphate-buffered saline (PBS) drops. Drugs were instilled 8 times/day for 72 h. Twenty-four and 96 h after inoculation of bacteria, the eyes were examined by slit lamp to assess corneal opacity. Corneas were removed to count bacteria. Results: Slit lamp examination showed that the corneal opacity scores were significantly lower in eyes that received propolis plus ciprofloxacin than in those treated with ciprofloxacin (p = 0.041) or propolis (p = 0.006) or control eyes treated with PBS (p = 0.0001). There was no significant difference in eyes treated with ciprofloxacin and propolis (p = 1.00). There were significantly fewer bacteria in eyes that received propolis plus ciprofloxacin than in those treated with ciprofloxacin (p = 0.0001) or propolis (p = 0.0001) or control eyes treated with PBS (p = 0.0001). There was no significant difference in eyes treated with ciprofloxacin and propolis (p = 0.38). Conclusions: Taking these findings into consideration, we suggest that the ethanolic extract of propolis has antimicrobial and anti-inflammatory properties for S. aureus keratitis. The combination of ciprofloxacin and propolis had better therapeutic effects than either agent alone. Copyright (C) 2005 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000087943
dc.identifier.endpage334en_US
dc.identifier.issn0030-3747
dc.identifier.issue6en_US
dc.identifier.pmid16138004en_US
dc.identifier.scopus2-s2.0-27344439868en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage328en_US
dc.identifier.urihttps://doi.org/10.1159/000087943
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11859
dc.identifier.volume37en_US
dc.identifier.wosWOS:000232667600006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofOphthalmic Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectpropolisen_US
dc.subjectflavonesen_US
dc.subjectkeratitis, experimentalen_US
dc.subjectStaphylococcus aureusen_US
dc.titleEffect of propolis in the treatment of experimental Staphylococcus aureus keratitis in rabbitsen_US
dc.typeArticleen_US

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