The first involved joints and associated factors in patients with rheumatoid arthritis

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dc.authoridoguzman, hamdi/0000-0003-1412-7689
dc.contributor.authorPekdiker, Mete
dc.contributor.authorOguzman, Hamdi
dc.date.accessioned2024-09-18T20:02:46Z
dc.date.available2024-09-18T20:02:46Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectives: This study aimed to investigate the first involved joints and associated factors in Turkish patients with rheumatoid arthritis (RA). Patients and methods: This retrospective cross-sectional study included 300 newly diagnosed and disease-modifying antirheumatic drug-na & iuml;ve RA patients (240 females, 60 males; mean age: 54 +/- 1.2 years; range, 18 to 82 years). Baseline demographic, clinical, and laboratory data were evaluated between January 2022 and December 2022. The patients were divided into four groups according to autoantibody profile: antibody-negative patients (Group 1; both RF and anti-CCP were negative in this group of patients), RF-positive patients (Group 2), anti-CCP-positive patients (Group 3), and patients with dual seropositivity with RF and antiCCP (Group 4). The patients were also divided into two groups according to the size of the first affected joint: patients with SJI at diagnosis and patients without SJI involvement at diagnosis. Results: Rheumatoid factor (RF) and anti-cyclic citrullinated peptide (CCP) antibody positivity rates were 40.3% and 35.6%, respectively. The mean lag time to diagnosis was 25 +/- 36 months. At the disease onset, 20% of patients did not have small joint involvement (SJI). Seronegative patients tended to be female (p=0.001), had longer lag time (p=0.001), and had lower levels of C-reactive protein (p=0.025), white blood count (p=0.005), and neutrophil/lymphocyte ratio (p=0.001) compared to the dual seropositive group. Patients presenting with SJI had a younger age (p=0.002), tended to be female (p=0.001), and had lower RF (p=0.034) and anti-CCP (p=0.031) positivity. Only age (p=0.005) and dual seronegativity (RF and anti-CCP; p=0.035) were the independent predictors of SJI in multivariate analysis. Conclusion: The decreasing age and seronegative status were defined as independent risk factors of SJI at the onset of RA. Population-based, prospective studies are needed for earlier diagnosis.en_US
dc.description.sponsorshipFunding: The authors received no financial support for the research and/or authorship of this article.en_US
dc.identifier.doi10.46497/ArchRheumatol.2024.10417
dc.identifier.endpage284en_US
dc.identifier.issn2618-6500
dc.identifier.issue2en_US
dc.identifier.pmid38933716en_US
dc.identifier.scopus2-s2.0-85194197983en_US
dc.identifier.scopusquality#BAŞV!en_US
dc.identifier.startpage274en_US
dc.identifier.urihttps://doi.org/10.46497/ArchRheumatol.2024.10417
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8016
dc.identifier.volume39en_US
dc.identifier.wosWOS:001304261300011en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish League Against Rheumatismen_US
dc.relation.ispartofArchives of Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAuto-antibodiesen_US
dc.subjectearly rheumatoid arthritisen_US
dc.subjectrheumatoid arthritisen_US
dc.subjectrisk factoren_US
dc.subjectsmall joint.en_US
dc.titleThe first involved joints and associated factors in patients with rheumatoid arthritisen_US
dc.typeArticleen_US

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