Multifunctional Materials for Cancer Therapy: From Antitumoral Agents to Innovative Administration

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dc.authoridGHICA, Mihaela Violeta/0000-0001-6853-9203
dc.authoridFICAI, Anton/0000-0002-1777-0525
dc.authoridRadulescu, Marius/0000-0002-5027-1138
dc.authoridSpoiala, Angela/0000-0001-8362-8845
dc.authoridYipel, Mustafa/0000-0002-6390-9313
dc.authoridFicai, Denisa/0000-0003-1243-6904
dc.contributor.authorYipel, Mustafa
dc.contributor.authorGhica, Mihaela V.
dc.contributor.authorKaya, Madalina G. Albu
dc.contributor.authorSpoiala, Angela
dc.contributor.authorRadulescu, Marius
dc.contributor.authorFicai, Denisa
dc.contributor.authorFicai, Anton
dc.date.accessioned2024-09-18T20:06:25Z
dc.date.available2024-09-18T20:06:25Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBy the developmentof new antineoplastic drugs addressed tospecific sites (key to tumor growth), targeted agents, which do not interfere with most normal cells have many advantages like fewer side effects (as personalized treatment), and prolonged survival time of cancer patients compared to conventional therapy. As current approaches in cancer therapy, drug delivery systems based on polymers (synthetic, natural or combinations like micelles, nanospheres, nanocapsules, nanogels, polymer-drug conjugates, polymer-drug polyplex, polymersomes) are more benefic compared to parent free drug, because of targeted effect of delivery, low toxicity, solubility in biological fluids and immunostimulatory effects. Synthetic polymers (polyesters, polyamides and polyethers) are the most used core materials for drug delivery systems, many of them being officially certified. On the other hand due to their better biocompatibility and biodegradability, the natural ones (polysaccharides and proteins) are still a hot topic on cancer therapy as drug delivery and targeting materials. This article reviews the multifunctional materials used in targeting of drugs with polymer based delivery systems as current-day data and key of future applications on cancer therapy. An increasing interest in the last decades returns to the new, engineered inorganic materials as well as to the newly optimized composites and nanocomposites.en_US
dc.description.sponsorshipUEFISCDI [PN-II-PT-PCCA-2013-4-0270]en_US
dc.description.sponsorshipAuthors recognize financial support from the UEFISCDI through PN-II-PT-PCCA-2013-4-0270 project: Ligament reconstruction by using advanced structural materials based on natural and synthetic polymers - LigaSint.en_US
dc.identifier.doi10.2174/1385272820666160919112919
dc.identifier.endpage2948en_US
dc.identifier.issn1385-2728
dc.identifier.issn1875-5348
dc.identifier.issue28en_US
dc.identifier.scopus2-s2.0-84995961411en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage2934en_US
dc.identifier.urihttps://doi.org/10.2174/1385272820666160919112919
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8506
dc.identifier.volume20en_US
dc.identifier.wosWOS:000390348100002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofCurrent Organic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCanceren_US
dc.subjecttarget therapeuticsen_US
dc.subjectdrug delivery systemsen_US
dc.subjectpolymersen_US
dc.subjectinorganic materialsen_US
dc.subjectcomposites and nanocompositesen_US
dc.titleMultifunctional Materials for Cancer Therapy: From Antitumoral Agents to Innovative Administrationen_US
dc.typeReview Articleen_US

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