The protective role of topical propolis on experimental keratitis via nitric oxide levels in rabbits

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dc.contributor.authorDuran, N
dc.contributor.authorKoc, A
dc.contributor.authorOksuz, H
dc.contributor.authorTamer, C
dc.contributor.authorAkaydin, Y
dc.contributor.authorKozlu, T
dc.contributor.authorÇelik, M
dc.date.accessioned2024-09-18T20:19:57Z
dc.date.available2024-09-18T20:19:57Z
dc.date.issued2006
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate antioxidant, anti-inflammatory, and antibacterial properties of propolis in the treatment of experimental Staphylococcus aureus keratitis. Twenty young New Zealand white rabbits were used in this experiment. Staphylococcus aureus were given by intrastromal injection to 16 rabbits and 4 rabbits were used as control group (Group 1). Group 2 was treated with phosphate-buffered solution drops; Group 3 was administered ethanolic extract of propolis drops; Group 4 received topical ciprofloxacin drops; Group 5 was treated with topical ciprofloxacin drops along with ethanolic extract of propolis drops. The eyes were examined by slit lamp to assess corneal opacity. And then, corneas were removed to determine nitric oxide (NO) levels and count bacteria. Corneas were also evaluated histologically. Corneal NO concentration in gruop 5, treated with a combination of propolis and ciprofloxacin was determined significantly lower (10.0 +/- 1.8 mu mol/g wet tissue) than in Group 4, treated with ciprofloxacin (24.0 +/- 3.1 mu mol/g wet tissue), from Group 3, treated with propolis (15.6 +/- 1.8 mu mol/g wet tissue), and treated with PBS (44.7 +/- 7.8 mu mol/g wet tissue). There were significantly fewer bacteria in eyes that received propolis plus ciprofloxacin than in eyes treated with ciprofloxacin (p=0.0001) or propolis (p=0.0001) or eyes treated with PBS (p=0.0001). The light microscopic examination revealed that the control group showed normal corneal morphology. In the nontreated group, sections of the stromal infiltration revealed the presence of inflammatory cells, which were diffusely distributed (p < 0.05). Administrations of ciprofloxacin plus propolis resulted in a significantly reduced histological damage with fewer bacterial inoculation of the corneal stroma in comparison with the other groups (p < 0.05). Based on these findings, we suggest that ethanolic extract of propolis has antioxidant, anti-inflammatory, and antibacterial properties for S. aureus keratitis in rabbits.en_US
dc.identifier.doi10.1007/s11010-006-0720-4
dc.identifier.endpage161en_US
dc.identifier.issn0300-8177
dc.identifier.issue1-2en_US
dc.identifier.pmid16328968en_US
dc.identifier.scopus2-s2.0-29944435949en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage153en_US
dc.identifier.urihttps://doi.org/10.1007/s11010-006-0720-4
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9970
dc.identifier.volume281en_US
dc.identifier.wosWOS:000233738200017en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular and Cellular Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectexperimental keratitisen_US
dc.subjectlight microscopyen_US
dc.subjectnitric oxideen_US
dc.subjectpropolisen_US
dc.subjectStaphylococcus aureusen_US
dc.titleThe protective role of topical propolis on experimental keratitis via nitric oxide levels in rabbitsen_US
dc.typeArticleen_US

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