Vancomycin and high-level aminoglycoside resistance in Enterococcus species

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dc.contributor.authorKurtgoz, Seyda Ozarslan
dc.contributor.authorOzer, Burcin
dc.contributor.authorInci, Melek
dc.contributor.authorDuran, Nizami
dc.contributor.authorYula, Erkan
dc.date.accessioned2024-09-18T20:16:56Z
dc.date.available2024-09-18T20:16:56Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Ãœniversitesien_US
dc.description.abstractThe aim of the study was to investigate vancomycin and high-level aminoglycoside resistance (HLAR) in Enterococcus species by phenotypic and genotypic methods. A hundred Enterococcus strains were included in the study. Antimicrobial susceptibilities of strains were investigated by automated system, betal-actamase production was investigated by nitrocefin disks, vancomycin resistance and HLAR were investigated by gradient diffusion method (GDM) and disk diffusion method, respectively. For detection of vancomycin and high-level gentamicin resistance (HLGR) genes, polymerase chain reaction was used. Teicoplanin linezolid, vancomycin, ampicillin, penicillin are the most susceptible antibiotics and strains were detected not to produce beta lactamase. Vancomycin resistance was detected in ten isolates by automated system and in only five isolates by GDM. Five isolates carrying VanA gene were determined. The ratio of HLGR and high-level streptomycin resistance was found 40 and 63% respectively. aac (6')-1eaph (2'')-1a-gene was detected in 58% of strains. E. faecium strains were found more resistant to the antibiotics than the other species. Beta lactamase was detected in none of strains. The automated system detected vancomycin resistance in more strains than GDM. Therefore it is concluded that strains, which were detected to be resistant to vancomycin, should be confirmed by GDM. The ratio of VanA gene in strains is consistent with other studies. The HLAR ratio was found in about half of strains. The ratio of aac(6')-1e-aph(2'')-1a gene, which is the most reported gene in our country and other countries and one of the HLGR genes investigated in our study, was detected 58%.en_US
dc.description.sponsorshipMustafa Kemal University Scientific Research Projects [BAP 1204 U 0107]en_US
dc.description.sponsorshipthis study was granted by Mustafa Kemal University Scientific Research Projects (BAP 1204 U 0107). The authors declare that they have no conflict of interest. The authors have no financial conflicts of interest. Ethical Approval was given, by Mersin University Ethical Committee.en_US
dc.identifier.doi10.4081/mr.2016.6441
dc.identifier.endpage28en_US
dc.identifier.issn2036-7481
dc.identifier.issue1en_US
dc.identifier.startpage23en_US
dc.identifier.urihttps://doi.org/10.4081/mr.2016.6441
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9818
dc.identifier.volume7en_US
dc.identifier.wosWOS:000413202200005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofMicrobiology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEnterococcusen_US
dc.subjectbeta lactamaseen_US
dc.subjectvancomycinen_US
dc.subjecthigh-level aminoglycosideen_US
dc.subjectresistanceen_US
dc.titleVancomycin and high-level aminoglycoside resistance in Enterococcus speciesen_US
dc.typeArticleen_US

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