Determination of ethyl glucuronide (EtG) in blood samples using partial least squares discriminant analysis applied to surface-enhanced Raman spectroscopy

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dc.authoridAcikgoz, Gunes/0000-0001-9118-3153
dc.contributor.authorAcikgoz, Gunes
dc.contributor.authorHamamci, Berna
dc.date.accessioned2024-09-18T20:19:54Z
dc.date.available2024-09-18T20:19:54Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractConsumption of alcohol and problems related to alcohol vary widely around the world. Especially illegally produced and distributed alcohols have a great risk for human health, since they include high quantity of toxic substances. Ethanol measurements have high specificity for excessive alcohol intake. Ethyl Glucuronide (EtG) is considered as a direct biomarker of recent ethanol consumption. The study aims to identify EtG in blood samples by using Raman Spectroscopy. Silver colloidal nanoparticles were synthesized to obtain SERS (Surface-Enhanced Raman Spectroscopy) spectra of blood samples and EtG. PLS-DA (Partial Least Squares Discriminant Analysis) models were built on the collected SERS spectra. It is observed that EtG and the blood samples taken from people using alcohol are in the same group and the blood samples taken from no alcohol users are in a separate cluster from EtG. The sources of data variability are modelled by the so-called Latent Variables (LVs). The percentage of LVs were found to be 29.53% and 8.34%, respectively. In the study, it has been observed that the level of EtG changes according to the level of ethanol in blood samples. However, there is no study on the detection of EtG in blood with Raman spectroscopy. Outcomes of the present study encourage the feasibility of the application of Raman Spectroscopy for determination of EtG in blood samples.en_US
dc.identifier.doi10.1016/j.vibspec.2019.103012
dc.identifier.issn0924-2031
dc.identifier.issn1873-3697
dc.identifier.scopus2-s2.0-85076630325en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.vibspec.2019.103012
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9940
dc.identifier.volume106en_US
dc.identifier.wosWOS:000507463100010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofVibrational Spectroscopyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEthyl glucuronide (EtG)en_US
dc.subjectRaman spectroscopyen_US
dc.subjectAlcoholen_US
dc.subjectChemometric methodsen_US
dc.subjectBlooden_US
dc.titleDetermination of ethyl glucuronide (EtG) in blood samples using partial least squares discriminant analysis applied to surface-enhanced Raman spectroscopyen_US
dc.typeArticleen_US

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