PHENOLIC COMPOSITION, ANTIOXIDANT CAPACITY OF SALVIA VERTICCILATA AND EFFECT ON MULTIDRUG RESISTANT BACTERIA BY FLOW-CYTOMETRY

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dc.contributor.authorTekeli, Yener
dc.contributor.authorKarpuz, Esra
dc.contributor.authorDanahaliloglu, Hatice
dc.contributor.authorBucak, Serbay
dc.contributor.authorGuzel, Yelda
dc.contributor.authorErdmann, Helmuth
dc.date.accessioned2024-09-18T20:56:50Z
dc.date.available2024-09-18T20:56:50Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: Antioxidants are of great importance for preventing oxidative stress that may cause several degenerative diseases. Studies have indicated phytochemicals have high free-radical scavenging activity, which helps to reduce the risk of chronic diseases. The aim of the present study is the determination of antioxidant properties, polyphenolic content and multidrug resistant bacteria of Salvia verticcilata L. Materials and Methods: Methanol was used as the extraction solvent. The total phenolic content was calculated using Folin-Ciocalteau method and phenolic composition was determined by HPLC. The radical scavenging activity of plant was evaluated in vitro based on the reduction of the stable DPPH free radical. The reducing capacity was identified by using the FRAP method. The ability of Salvia verticcilata L. to increase the permeability of multidrug resistant bacterial cells was conducted by flow cytometric assay on Listeria innocua and E-coli. Results: The amount of total phenolics was found to be 347.5 mg GA/g extract. The IC50 value and FRAP assay are 0.61, and 0.944 respectively, Free radical scavenging effect and FRAP values are less than synthetic antioxidant compounds (BHA and BHT). Eight phenolic compounds were found in Salvia verticcilata L. Intense concentration of S. verticcilata L. has destroyed 97 % of living cells for Listeria innocua and 94.86% for E-coli Conclusion: This studyshows that methanolic extracts of Salvia verticcilata L. is a potential source of natural antioxidants and antimicrobial agent and can form the basis for pharmacological studies.en_US
dc.description.sponsorshipMustafa Kemal University Scientific Research Projects Coordination Unit (BAP) in Hatay, Turkey [212]en_US
dc.description.sponsorshipThe present work is supported by Mustafa Kemal University Scientific Research Projects Coordination Unit (BAP) in Hatay, Turkey. (Project number: 212)en_US
dc.identifier.doi10.4314/ajtcam.v11i4.23
dc.identifier.endpage152en_US
dc.identifier.issn0189-6016
dc.identifier.issue4en_US
dc.identifier.pmid25392595en_US
dc.identifier.scopus2-s2.0-84924700666en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage147en_US
dc.identifier.urihttps://doi.org/10.4314/ajtcam.v11i4.23
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12112
dc.identifier.volume11en_US
dc.identifier.wosWOS:000338347300023en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAfrican Networks Ethnomedicinesen_US
dc.relation.ispartofAfrican Journal of Traditional Complementary and Alternative Medicinesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSalvia verticcilataen_US
dc.subjectmedicinal planten_US
dc.subjectantioxidanten_US
dc.subjectphenolic compositionen_US
dc.subjectmultidrug resistanten_US
dc.titlePHENOLIC COMPOSITION, ANTIOXIDANT CAPACITY OF SALVIA VERTICCILATA AND EFFECT ON MULTIDRUG RESISTANT BACTERIA BY FLOW-CYTOMETRYen_US
dc.typeArticleen_US

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