Association of CagA and VacA presence with ulcer and non-ulcer dyspepsia in a Turkish population

Basit Öğe Kaydı
dc.authoridKarincaoglu, Melih/0000-0002-9727-5128
dc.contributor.authorBulent, K
dc.contributor.authorMurat, A
dc.contributor.authorEsin, A
dc.contributor.authorFatih, K
dc.contributor.authorMMMurat, H
dc.contributor.authorHakan, H
dc.contributor.authorMelih, K
dc.date.accessioned2024-09-18T21:06:39Z
dc.date.available2024-09-18T21:06:39Z
dc.date.issued2003
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAIM: The mostly known genotypic virulence features, of H. pylori are cytotoxin associated gene A (cagA) and Vacuolating cytotoxin gene A (VacA). We investigated the association of these major virulence factors with ulcer an non-ulcer dyspepsia in our region. METHODS: One hundred and forty two dyspeptic patients were studied (average age 44.8+/-15.9 years, range 15-87 years, 64 males and 78 females). Antral and corpus biopsies were taken for detecting and genotyping of H. pylori. 107 patients who were H. pylori positive by histological assessment were divided into three groups according to endoscopic findings: Duodenal ulcer (DU), gastric ulcer (GU) and non-ulcer dyspepsia (NUD). The polymerase chain reaction (PCR) was used to detect CagA and VacA genes of H. pylori using specific primers. RESULTS: H. pylori was isolated from 75.4 % (107/142) of the patients. Of the 107 patients, 66 (61.7 %) were cagA- positive and 82 (76.6 %) were VacA-positive. CagA gene was positively associated with DU and GU (P<0.01, P<0.02), but not with NUD (P>0.05). Although VacA positivity in ulcer patients was higher than that in NUD group, the difference was not statistically significant (P>0.05). CONCLUSION: There is a significantly positive association between CagA genes and DU and GU. The presence of VacA is not a predictive marker for DU, GU, and NUD in our patients.en_US
dc.identifier.doi10.3748/wjg.v9.i7.1580
dc.identifier.endpage1583en_US
dc.identifier.issn1007-9327
dc.identifier.issn2219-2840
dc.identifier.issue7en_US
dc.identifier.pmid12854168en_US
dc.identifier.scopus2-s2.0-0041563702en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1580en_US
dc.identifier.urihttps://doi.org/10.3748/wjg.v9.i7.1580
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13743
dc.identifier.volume9en_US
dc.identifier.wosWOS:000185377600043en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBaishideng Publishing Group Incen_US
dc.relation.ispartofWorld Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHelicobacter-Pylori Antigensen_US
dc.subjectVacuolating Cytotoxin Geneen_US
dc.subjectPeptic-Ulceren_US
dc.subjectVirulence Factorsen_US
dc.subjectDuodenal-Ulceren_US
dc.subjectPathogenicity Islanden_US
dc.subjectSerological Responseen_US
dc.subjectInfected Patientsen_US
dc.subjectGastric Lymphomaen_US
dc.subjectSerum Antibodiesen_US
dc.titleAssociation of CagA and VacA presence with ulcer and non-ulcer dyspepsia in a Turkish populationen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Tam Metin / Full Text
Boyut:
117.92 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu