Is atopy and autoimmunity more prevalent in patients with alopecia areata? A comparative study

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dc.contributor.authorSerarslan, G.
dc.contributor.authorSavas, N.
dc.contributor.authorYenin, J. Z.
dc.date.accessioned2024-09-18T21:05:19Z
dc.date.available2024-09-18T21:05:19Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective We aimed to determine whether there was a difference between adult and paediatric alopecia areata patients with respect to the severity and pattern of the disease, nail changes and personal and family history of autoimmune diseases and also in comparison with controls. Methods Two groups were included: patients with onset of alopecia before the age of =18 years and >18 years. The total number of the patients were 124. The control group was comprised of 114 age- and gender-matched patients. Results There were 81 adults and 43 children. No statistically significant difference was present between disease severity and gender, age, personal and family history of autoimmune disease in the adult and paediatric group (P > 0.5). Thirteen adults with scalp involvement had nail changes. 61.5% had mild and 38.46% had severe disease (P > 0.5). Of the 43 paediatric patients, 10 patients had nail changes. Severe alopecia was present in 40% of patients with nail changes; however, 9.1% had severe alopecia in patients without nail changes (P = 0.04). There was no statistical significance in patients with and without familial autoimmune diseases when compared with pattern and severity of the diseases between the two groups. Conclusion The frequencies of autoimmune and atopic diseases were not different between adult and paediatric patients and the control group. We did not find a statistically significance between disease severity and personal and family history of autoimmune disease in the two groups. Disease severity was not related to nail changes in the adult group. However, severe alopecia areata was more prevalent in children with nail changes. Furthermore, ophiasis pattern was more prevalent in the paediatric group with nail changes compared with the adult group.en_US
dc.identifier.doi10.1111/j.1468-3083.2011.04152.x
dc.identifier.endpage723en_US
dc.identifier.issn0926-9959
dc.identifier.issue6en_US
dc.identifier.pmid21692870en_US
dc.identifier.scopus2-s2.0-80053519563en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage720en_US
dc.identifier.urihttps://doi.org/10.1111/j.1468-3083.2011.04152.x
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13515
dc.identifier.volume26en_US
dc.identifier.wosWOS:000304397900010en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofJournal of The European Academy of Dermatology and Venereologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFamily-Historyen_US
dc.subjectChildrenen_US
dc.subjectSingaporeen_US
dc.subjectProfileen_US
dc.titleIs atopy and autoimmunity more prevalent in patients with alopecia areata? A comparative studyen_US
dc.typeArticleen_US

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