Impact of enriched environment on production of tau, amyloid precursor protein and, amyloid-? peptide in high-fat and high-sucrose-fed rats

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dc.authoridSelvi, Yavuz/0000-0003-0218-6796
dc.authoridKandeger, Ali/0000-0001-6940-0940
dc.authoridgergerlioglu, hasan serdar/0000-0002-8836-0726
dc.contributor.authorSelvi, Yavuz
dc.contributor.authorGergerlioglu, Hasan Serdar
dc.contributor.authorAkbaba, Nursel
dc.contributor.authorOz, Mehmet
dc.contributor.authorKandeger, Ali
dc.contributor.authorDemir, Enver Ahmet
dc.contributor.authorYerlikaya, Fatma Humeyra
dc.date.accessioned2024-09-18T19:54:15Z
dc.date.available2024-09-18T19:54:15Z
dc.date.issued2017
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: The Western-type diet is associated with an elevated risk of Alzheimer's disease and other milder forms of cognitive impairment. The aim of the present study was to investigate the effects of the environmental enrichment on amyloid and tau pathology in high-fat and high-sucrose-fed rats. Methods: In total, 40 adult male rats were categorised into two main groups according to their housing conditions: enriched environment (EE, n = 16) and standard housing condition (n = 24). The groups were further divided into five subgroups that received standard diet, high-fat diet, and high-sucrose diet. We performed the analysis of amyloid beta-peptide (A beta) (1-40), A beta(1-42), amyloid precursor protein (APP), and tau levels in the hippocampus of rats that were maintained under standard housing conditions or exposed to an EE. Results: The EE decreased the A beta(1-40), A beta(1-42), APP, and tau levels in high-fat and high-sucrose-fed rats. Conclusion: This observation shows that EE may rescue diet-induced amyloid and tau pathology.en_US
dc.description.sponsorshipSelcuk University Scientific Research Projects Coordination Unit [15401033]en_US
dc.description.sponsorshipThe authors thank the Selcuk University Scientific Research Projects Coordination Unit for the financial support (Project No.: 15401033).en_US
dc.identifier.doi10.1017/neu.2016.63
dc.identifier.endpage298en_US
dc.identifier.issn1601-5215
dc.identifier.issue5en_US
dc.identifier.pmid27923413en_US
dc.identifier.scopus2-s2.0-85001610082en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage291en_US
dc.identifier.urihttps://doi.org/10.1017/neu.2016.63
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7601
dc.identifier.volume29en_US
dc.identifier.wosWOS:000415942300004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofActa Neuropsychiatricaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectamyloiden_US
dc.subjectdieten_US
dc.subjecthippocampusen_US
dc.subjecttauen_US
dc.titleImpact of enriched environment on production of tau, amyloid precursor protein and, amyloid-? peptide in high-fat and high-sucrose-fed ratsen_US
dc.typeArticleen_US

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