Antidepressant-like effects of quercetin in diabetic rats are independent of hypothalamic-pituitary-adrenal axis

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dc.authoridDemir, Enver/0000-0002-2620-6192
dc.authoridgergerlioglu, hasan serdar/0000-0002-8836-0726
dc.contributor.authorDemir, Enver Ahmet
dc.contributor.authorGergerlioglu, Hasan Serdar
dc.contributor.authorOz, Mehmet
dc.date.accessioned2024-09-18T19:50:24Z
dc.date.available2024-09-18T19:50:24Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective Quercetin, one of the most potent flavonol in the family of flavonoids, has been shown to have benefits against diabetes and its complications. In the present study, we investigated effects of quercetin on depression-like behaviours and hypothalamic-pituitary-adrenal (HPA) axis in diabetic rats. Methods Experimental diabetes was induced by using streptozotocin, and either 50 or 100 mg/kg quercetin was intraperitoneally administered for 21 days. Following the last treatment, animals were subjected to the forced swim test, and subsequently, the blood was obtained by cardiac puncture to measure plasma adrenocorticotropic hormone (ACTH) and corticosterone (CORT) levels. Results A significant increase of the total immobile time, accompanied by a decrease in the immobility latency, which suggests a depressive status, was observed in diabetic animals that was reversed by the treatment of 50 mg/kg quercetin. However, the higher dose of quercetin (100 mg/kg) was ineffective in alleviating depression-like behaviours. The plasma concentrations of ACTH, and total- and free-CORT were not affected by both doses of quercetin. Conclusion Therefore, we concluded that the antidepressant-like effects of quercetin in diabetes are independent of the HPA axis.en_US
dc.description.sponsorshipSelcuk University Faculty Development Project Coordination Unit [2013-OYP-089]en_US
dc.description.sponsorshipThis manuscript is based on parts of a doctoral dissertation submitted to the Department of Physiology, Faculty of Medicine, Selcuk University (Konya, Turkey) and supported by Selcuk University Faculty Development Project Coordination Unit (2013-OYP-089). Preliminary results were presented as an abstract at the 40th National Congress of Physiology, Kayseri, Turkey, September 2-6, 2014. We would like to express our sincere thanks to Ender Erdogan, MD, Ph.D., Ersin Fadillioglu, MD, and Hakki Gokbel, MD for their insightful comments.en_US
dc.identifier.doi10.1017/neu.2015.45
dc.identifier.endpage30en_US
dc.identifier.issn1601-5215
dc.identifier.issue1en_US
dc.identifier.pmid26234153en_US
dc.identifier.scopus2-s2.0-84952873765en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage23en_US
dc.identifier.urihttps://doi.org/10.1017/neu.2015.45
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7419
dc.identifier.volume28en_US
dc.identifier.wosWOS:000367182200003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofActa Neuropsychiatricaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadrenocorticotropic hormoneen_US
dc.subjectcorticosteroneen_US
dc.subjectdepressionen_US
dc.subjectexperimental diabetes mellitusen_US
dc.subjectquercetinen_US
dc.titleAntidepressant-like effects of quercetin in diabetic rats are independent of hypothalamic-pituitary-adrenal axisen_US
dc.typeArticleen_US

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