Neuroimaging Findings in Pediatric Patients with Thalassemia Major

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dc.authoridKoker, Alper/0000-0003-1231-3023
dc.authoridAKBAS, Yilmaz/0000-0003-3919-4685
dc.authoridAydin, Sultan/0000-0002-8801-7776
dc.contributor.authorAkbas, Yilmaz
dc.contributor.authorAydin, Sultan
dc.contributor.authorTuncer, Gokcen Oz
dc.contributor.authorKoker, Alper
dc.contributor.authorCoban, Yasemin
dc.contributor.authorOktay, Gonul
dc.contributor.authorYeral, Hakan
dc.date.accessioned2024-09-18T20:59:21Z
dc.date.available2024-09-18T20:59:21Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: Cranial magnetic resonance imaging (MRI) studies about iron accumulation in children with thalassemia major are quite limited. Aim: This study aimed to detect neurological findings with cranial MRIs in the pediatric patients with thalassemia major who did not develop any neurological complications. Materials and Methods: Pediatric patients with thalassemia major who followed in the Pediatric Hematology Unit between 1 July 2017 and 1 January 2019 were included in the study. The patients underwent cranial MRI scans. Results: A total of 30 patients were included. The median age was 15 (range from 4-18) years old. We found that 7 patients had a splenectomy and 19 of the remaining 23 patients had splenomegaly. In addition, 13 of the patients had hepatomegaly, 10 had skeletal deformities, and 17 had growth retardation. The mean ferritin level was 3772.3 +/- 2524.8. We detected various pathologies on cranial MRI images of 10 (33.3%) patients. In 3 of these patients, millimeter-sized ischemia-compatible lesions were found in the cerebral white matter, which did not fit any arterial area, and 5 patients had hyperintense lesions in the basal ganglia. Conclusion: Our study is valuable since 1/3 of our pediatric patients with thalassemia major were detected with intracranial pathology.en_US
dc.identifier.doi10.3390/hematolrep14010009
dc.identifier.endpage60en_US
dc.identifier.issn2038-8322
dc.identifier.issn2038-8330
dc.identifier.issue1en_US
dc.identifier.pmid35323180en_US
dc.identifier.scopus2-s2.0-85128755546en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage54en_US
dc.identifier.urihttps://doi.org/10.3390/hematolrep14010009
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12532
dc.identifier.volume14en_US
dc.identifier.wosWOS:000775419800001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofHematology Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectthalassemia majoren_US
dc.subjectcranial MRIen_US
dc.subjectneurological complicationsen_US
dc.subjecthemoglobinopathyen_US
dc.titleNeuroimaging Findings in Pediatric Patients with Thalassemia Majoren_US
dc.typeArticleen_US

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