Ameliorating effect of kisspeptin-10 on methotrexate-induced sperm damages and testicular oxidative stress in rats

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dc.authoridGUVENC, MEHMET/0000-0002-9716-0697
dc.contributor.authorGuvenc, Mehmet
dc.contributor.authorAksakal, Mesut
dc.date.accessioned2024-09-18T20:28:18Z
dc.date.available2024-09-18T20:28:18Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe purpose of this study was to determine the kisspeptin-10 (Kiss) administration on the damages in testicular oxidant-antioxidant system, reproductive organ weights and some spermatological characteristics resulted from methotrexate (MTX) exposure. Group 1 (n:6) received saline only; group 2 (n:6) received 50 nmol/kg kisspeptin-10 for 10 days; group 3 (n:10) received single-dose methotrexate 20 mg/kg; and group 4 (n:10) received MTX 20 mg/kg single dose and, after 3 days, received kisspeptin-10, 50 nmol/kg, lasted for 10 days by intraperitoneal injection. At the end of the study, malondialdehyde levels were found to have increased following the application of MTX while showing a significant reduction in group 4 with Kiss administration. With respect to the spermatological parameters, administering MTX decreased motility and increased the rates of abnormal spermatozoa in group 2, while improvements were observed in group 4 in the form of increased motility in the spermatozoa and fewer abnormal spermatozoa. In addition, Kiss treatment provided statistically significant increases in the absolute weight of the seminal vesicles and the relative weights of the right cauda epididymis and seminal vesicles resulting from MIX administration. MTX administration damaged some spermatological parameters and increased oxidative stress when compared to the control group. However, Kiss treatment was observed to mitigate these adverse effects as demonstrated by the improvements in coadministration of Kiss and MTX when compared to the MTX group. It is concluded that Kiss treatment may reduce MTX-induced reproductive toxicity as a potential antioxidant compound.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Firat University [VF.14.18]en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Firat University, Grant/Award Number: VF.14.18en_US
dc.identifier.doi10.1111/and.13057
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue8en_US
dc.identifier.pmid29862548en_US
dc.identifier.scopus2-s2.0-85053564425en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1111/and.13057
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10832
dc.identifier.volume50en_US
dc.identifier.wosWOS:000444797600003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectkisspeptinen_US
dc.subjectmethotrexateen_US
dc.subjectoxidative stressen_US
dc.subjectsperm qualityen_US
dc.titleAmeliorating effect of kisspeptin-10 on methotrexate-induced sperm damages and testicular oxidative stress in ratsen_US
dc.typeArticleen_US

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