The effects of zoledronic acid on neointimal hyperplasia: a rabbit carotid anastomosis model

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dc.contributor.authorGuzeloglu, Mehmet
dc.contributor.authorGul, Mehmet
dc.contributor.authorReel, Buket
dc.contributor.authorYurekli, Ismail
dc.contributor.authorAykut, Koray
dc.contributor.authorHazan, Eyup
dc.date.accessioned2024-09-18T20:33:09Z
dc.date.available2024-09-18T20:33:09Z
dc.date.issued2011
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: The aim of the present study was to investigate the effect of zoledronic acid (ZA), as a matrix metalloproteinase inhibitor, on neointimal hyperplasia in rabbit carotid anastomosis model. Methods: New Zealand male rabbits were divided into two groups as placebo and treatment groups in this experimental study. After anesthesia, the right carotid artery of each rabbit was end-to-end anastomosed with an 8/0 polypropylene suture. Left carotid artery was kept as control without any operation. Placebo group (n=6) received phosphate buffered saline (PBS) (0.5mL/kg/day/s.c.) for 28 days postoperatively, whereas ZA group (n=6) received ZA (100 mu g/kg/day/s.c.) for the same period. After sacrification, the anastomosed and control arteries were isolated. Morphometric and immunohistochemical examinations were performed. Statistical analyses of morphometric and immunohistochemical data were performed using two-way ANOVA and Chi-square test respectively. Results: In PBS group, vascular injury in the anastomosed artery significantly increased the intimal area (anastomosed: 112.51 +/- 61.18 mu m(2)*1000 vs. control: 22.62 +/- 4.26 mu m(2)*1000, p<0.01) and intima/media index (anastomosed: 0.347 +/- 0.29 vs. control: 0.075 +/- 0.01, p<0.05) compared to control artery. ZA significantly reduced the intimal area (39.29 +/- 18.21 mu m(2)*1000, p<0.01) and intima/media index (0.112 +/- 0.07, p<0.05) compared to PBS group. Additionally, a-smooth muscle actin immunopositivity was found significantly decreased in anastomosed arteries from ZA group (ZA: 2.33 +/- 0.52 vs. PBS: 3.50 +/- 0.5, p<0.05). Moreover, intensive gelatinase (MMP-2 and MMP-9) immunoreactivities were clearly seen in anastomosed arteries compared to control arteries from PBS group. ZA apparently decreased immunopositivities for gelatinases in anastomosed arteries. Conclusion: ZA might be a promising agent for prevention of neointimal hyperplasia, which is the most significant cause of graft failures in late postoperative period. (Anadolu Kardiyol Derg 2011; 11: 93-100)en_US
dc.identifier.doi10.5152/akd.2011.026
dc.identifier.endpage100en_US
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue2en_US
dc.identifier.pmid21285021en_US
dc.identifier.scopus2-s2.0-79952555429en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage93en_US
dc.identifier.urihttps://doi.org/10.5152/akd.2011.026
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11331
dc.identifier.volume11en_US
dc.identifier.wosWOS:000288827900002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Soc Cardiologyen_US
dc.relation.ispartofAnatolian Journal of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeointimalen_US
dc.subjectmatrix metalloproteinases (MMPs)en_US
dc.subjectzoledronic aciden_US
dc.subjectrabbiten_US
dc.titleThe effects of zoledronic acid on neointimal hyperplasia: a rabbit carotid anastomosis modelen_US
dc.typeArticleen_US

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