Imparting of Nearly Superparamagnetic Properties to Cryogel Scaffolds With Mesoporous MNPs for Magneto-Sensitive Tissue Engineering Strategies

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dc.contributor.authorDemir, Didem
dc.contributor.authorUlusal, Fatma
dc.contributor.authorUlusal, Hasan
dc.contributor.authorCeylan, Seda
dc.contributor.authorDagli, Sibel
dc.contributor.authorOzdemir, Nalan
dc.contributor.authorTarakcioglu, Mehmet
dc.date.accessioned2024-09-18T20:08:20Z
dc.date.available2024-09-18T20:08:20Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThis work reports the assembly of mesoporous iron oxide nanoparticles (meso-MNPs) with cryogel scaffolds composed of chitosan and gelatin. Meso-MNPs with a particle size ranging from 2 and 50 nm, a surface area of 140.52 m2 g-1, and a pore volume of 0.27 cm3 g-1 were synthesized on a porous SiO2 template in the presence of PEG 6000 followed by leaching of SiO2. Different ratios of meso-MNPs were successfully incorporated into chitosan:gelatin cryogels up to an amount equivalent to the entire amount of polymer. The morphological structure and physicochemical properties of the cryogels were directly affected by the amount of MNPs. VSM curves showed that all composite cryogels could be magnetized by applying a magnetic field. In the context of the safety of magnetic cryogel scaffolds for use in biomedicine, it is important to note that all values are below the exposure limit for static magnetic fields, and according to cytotoxicity data, scaffolds containing meso-MNPs showed nontoxicity with cell viability ranging from 150% to 275%. In addition, microbial analysis with gram-negative and gram-positive bacteria showed that the scaffolds exhibited activity against these bacteria. imageen_US
dc.description.sponsorshipThe authors would like to thank Dr. Idris Adanur for his contributions to the interpretation of the magnetic properties of MNPs. We would like to thank the Proofreading & Editing Office of the Dean for Research at Erciyes University for copyediting and proofreading service for this manuscript.en_US
dc.identifier.doi10.1002/bip.23623
dc.identifier.issn0006-3525
dc.identifier.issn1097-0282
dc.identifier.pmid39158278en_US
dc.identifier.scopus2-s2.0-85201545371en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/bip.23623
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8784
dc.identifier.wosWOS:001292996000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofBiopolymersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectchitosanen_US
dc.subjectcryogelen_US
dc.subjectgelatinen_US
dc.subjectmagnetic nanoparticleen_US
dc.subjectscaffolden_US
dc.subjecttissue engineeringen_US
dc.titleImparting of Nearly Superparamagnetic Properties to Cryogel Scaffolds With Mesoporous MNPs for Magneto-Sensitive Tissue Engineering Strategiesen_US
dc.typeArticleen_US

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