Protective Effect of Ellagic Acid on Paraquat-induced Kidney Hazards in Rats

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dc.authoridUYGUR, VELI/0000-0003-3971-7714
dc.contributor.authorSilfeler, Ibrahim
dc.contributor.authorAlp, Harun
dc.contributor.authorDorum, Bayram Ali
dc.contributor.authorNacar, Emel
dc.contributor.authorArslan, Selda
dc.contributor.authorUygur, Veli
dc.date.accessioned2024-09-18T20:16:47Z
dc.date.available2024-09-18T20:16:47Z
dc.date.issued2017
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIntroduction. Paraquat is a commonly used highly toxic herbicide. Despite many studies on detoxification of paraquat, an efficient and safe antidote has not been introduced for toxic cases in human being. The aim of this study was to investigate the effect of ellagic acid (EA) on paraquat-induced kidney hazards in rats. Materials and Methods. Sixty rats were randomly assigned as controls and 5 treatment groups (n = 10 each) receiving EA only, paraquat at doses of 15 mg/kg and 45 mg/kg, and paraquat at the same doses plus EA. Paraquat was intraperitoneally injected and the EA was orally given. Kidney tissues were stained with hematoxylin-eosin for histopathologic investigation. Results. Pathologic scoring showed that paraquat at the higher dose was associated with higher scores than the in the controls, EA group, and the high-dose paraquat group with EA treatment (P < .001 for all comparisons). It was noted that paraquat caused a serious damage in the kidney and the EA treatment significantly reduced the extent of the damage. Conclusions. This study showed the protective effects of EA against paraquat-induced nephrotoxicity histologically. Ellagic acid provided significant improvement in glomerular and tubular structure.en_US
dc.identifier.endpage28en_US
dc.identifier.issn1735-8582
dc.identifier.issn1735-8604
dc.identifier.issue1en_US
dc.identifier.pmid28174349en_US
dc.identifier.scopus2-s2.0-85011973306en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage23en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9750
dc.identifier.volume11en_US
dc.identifier.wosWOS:000396485800004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherIranian Soc Nephrolgyen_US
dc.relation.ispartofIranian Journal of Kidney Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectellagic aciden_US
dc.subjectintoxicationen_US
dc.subjectkidneyen_US
dc.subjectparaquaten_US
dc.titleProtective Effect of Ellagic Acid on Paraquat-induced Kidney Hazards in Ratsen_US
dc.typeArticleen_US

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