Thrombus aspiration in patients with ST elevation myocardial infarction: Meta-analysis of 16 randomized trials

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dc.authoridTanboga, Ibrahim Halil/0000-0003-4546-9227
dc.contributor.authorTanboga, Ibrahim Halil
dc.contributor.authorTopcu, Selim
dc.contributor.authorAksakal, Enbiya
dc.contributor.authorKurt, Mustafa
dc.contributor.authorKaya, Ahmet
dc.contributor.authorOduncu, Vecih
dc.contributor.authorSevimli, Serdar
dc.date.accessioned2024-09-18T20:59:25Z
dc.date.available2024-09-18T20:59:25Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: The mortality rate is high in some patients undergoing primary percutaneous coronary intervention (PPCI) because of ineffective epicardial and myocardial perfusion. The use of thrombus aspiration (TA) might be beneficial in this group but there is contradictory evidence in current trials. Therefore, using PRISMA statement, we performed a meta-analysis that compares PPCI+TA with PPCI alone. Methods: Sixteen studies in which PPCI (n=5262) versus PPCI+TA (n=5256) were performed, were included in this meta-analysis. We calculated the risk ratio (RR) for epicardial and myocardial perfusion, such as the Thrombolysis In myocardial Infarction (TIMI) flow, myocardial blush grade (MBG) and stent thrombosis (ST) resolution (STR), and clinical outcomes, such as all-cause death, recurrent infarction (Re-MI), target vessel revascularization/target lesion revascularization (TVR/TLR), stent thrombosis (ST), and stroke. Results: Postprocedural TIMI-III flow frequency, postprocedural MBG II-III flow frequency, and postprocedural STR were significantly high in TA+PPCI compared with the PPCI alone group. However, neither all-cause mortality [6.6% vs. 7.4%, RR=0.903, 95% confidence interval (CI): 0.785-1.038, p=0.149] nor Re-MI (2.3% vs. 2.6%, RR=0.884, 95% CI: 0.693-1.127, p=0.319), TVR/TLR (8.2% vs. 8.0%, RR=1.028, 95% CI: 0.900-1.174, p=0.687), ST (0.93% vs. 0.90%, RR=1.029, 95% CI: 0.668-1.583, p=0.898), and stroke (0.5% vs. 0.5%, RR=1.073, 95% CI: 0.588-1.959, p=0.819) rates were comparable between the groups. Conclusion: This meta-analysis is the first updated analysis after publishing the 1-year result of the Thrombus Aspiration during ST-Segment Elevation Myocardial Infarction trial, and it showed that TA did not reduce the rate of all-cause mortality, Re-MI, TVR/TLR, ST, and stroke.en_US
dc.identifier.doi10.5152/akd.2015.6114
dc.identifier.endpage187en_US
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue3en_US
dc.identifier.pmid25880174en_US
dc.identifier.scopus2-s2.0-84979092879en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage175en_US
dc.identifier.urihttps://doi.org/10.5152/akd.2015.6114
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12562
dc.identifier.volume15en_US
dc.identifier.wosWOS:000351850500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofAnatolian Journal of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectthrombus aspirationen_US
dc.subjectmeta-analysisen_US
dc.subjectST elevation myocardial infarctionen_US
dc.titleThrombus aspiration in patients with ST elevation myocardial infarction: Meta-analysis of 16 randomized trialsen_US
dc.typeArticleen_US

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