Iron-Induced Cerebellar Purkinje Cell Loss Is Ameliorated by Flunarizine

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dc.authoridNACAR, TUNCER/0000-0002-9287-7170
dc.authoridBOSTANCI, Mehmet Omer/0000-0002-2887-1073
dc.contributor.authorKozan, Ramazan
dc.contributor.authorBostanci, M. Oemer
dc.contributor.authorNacar, Tuncer
dc.contributor.authorAslan, Ali
dc.contributor.authorBagirici, Faruk
dc.date.accessioned2024-09-18T20:25:09Z
dc.date.available2024-09-18T20:25:09Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAim: In this study, we investigated the effect of intracerebroventricular-injected iron neurotoxicity on the total number of cerebellar Purkiinje cells in rats and the possible neuroprotective effect of flunarizine, a piperazine-derived calcium channel blocker. Materials and Methods: Rats were divided into four groups: control, flunarizine. iron, and iron + flunarizine groups. Rats in the iron and iron + flunarizine groups received intracerebro-ventricular iron (FeCl36H2O. 200 mM, 2.5 mu l), while those in flunarizine and iron + flunarizine groups were intraperitoneally injected with flunarizine (10 mg/kg/day) once a day after the operation for 10 days. After 10 days, all rats were perfused intracardially and then sacrificed. Brain tissues were removed and standard histological techniques were performed. The total numbers of Purkinje cells were estimated using unbiased stereological techniques. Results: Means of the total numbers of Purkinje cells in the cerebellum were estimated as 310441 +/- 6558, 298658 +/- 9636, 200201 +/- 6822 and 282658 +/- 6327 in the control, flunarizine, iron, and iron + flunarizine groups. respectively. Comparison between iron and iron + flunarizine groups revealed that flunarizine significantly attenuates the iron-induced neuron loss from 35.5% to 8.9% (P < 0.05). Conclusions: Findings of the present study suggest that flunarizine has a neuroprotective effect on iron-induced Purkinje cell loss in the rat cerebellum via blocking influx of calcium ions into neurons.en_US
dc.identifier.doi10.3906/sag-0712-2
dc.identifier.endpage42en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue1en_US
dc.identifier.startpage37en_US
dc.identifier.urihttps://doi.org/10.3906/sag-0712-2
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10117
dc.identifier.volume39en_US
dc.identifier.wosWOS:000264805800006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFlunarizineen_US
dc.subjectironen_US
dc.subjectneurotoxicityen_US
dc.subjectPurkinje cellen_US
dc.subjectstereologyen_US
dc.titleIron-Induced Cerebellar Purkinje Cell Loss Is Ameliorated by Flunarizineen_US
dc.typeArticleen_US

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