Effect of zinc on the lipid peroxidation and the antioxidant defense systems of the alloxan-induced diabetic rabbits

Basit Öğe Kaydı
dc.contributor.authorDuzguner, Vesile
dc.contributor.authorKaya, Sule
dc.date.accessioned2024-09-18T20:15:10Z
dc.date.available2024-09-18T20:15:10Z
dc.date.issued2007
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe effects of oral zinc supplementation on lipid peroxidation and the antioxidant defense system of alloxan (80-90 mg/kg)-induced diabetic rabbits were examined. Forty-five New Zealand male rabbits, 1 year old, weighing approximately 2.5 kg, were allocated randomly and equally as control, diabetic, and zinc-supplemented diabetic groups. After diabetes was induced, zinc-supplemented diabetic rabbits had 150 mg/L of zinc as zinc sulfate (ZnSO4) in their drinking tap water for 3 months. The feed and water consumption was higher in diabetic groups than (P < 0.01) healthy rabbits. The body weight was lower in diabetic rabbits compared to control. The blood glucose levels were higher in diabetic groups than controls. The elevated plasma malondialdehyde (MDA) levels were determined in the diabetic group (P < 0.01). The glutathione peroxidase (GSHPx), catalase (CAT), superoxide dismutase (SOD), glutathione (GSH), and ceruloplasmin levels in the diabetic group were decreased by the effect of diabetes but there was no difference between zinc-supplemented diabetic and control rabbits. Serum zinc concentrations were lower in diabetic rabbits but iron (Fe) and copper (Cu) levels in sera were not different among the groups. As a result, it was concluded that daily zinc supplementation could reduce the harmful effects of oxidative stress in diabetics. (c) 2007 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.freeradbiomed.2007.02.021
dc.identifier.endpage1486en_US
dc.identifier.issn0891-5849
dc.identifier.issn1873-4596
dc.identifier.issue10en_US
dc.identifier.pmid17448894en_US
dc.identifier.scopus2-s2.0-34247130390en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1481en_US
dc.identifier.urihttps://doi.org/10.1016/j.freeradbiomed.2007.02.021
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9486
dc.identifier.volume42en_US
dc.identifier.wosWOS:000246164500003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofFree Radical Biology and Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdiabetesen_US
dc.subjectzincen_US
dc.subjectrabbitsen_US
dc.subjectlipid peroxidationen_US
dc.subjectantioxidantsen_US
dc.titleEffect of zinc on the lipid peroxidation and the antioxidant defense systems of the alloxan-induced diabetic rabbitsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ N/A ]
İsim:
Tam Metin / Full Text
Boyut:
155.14 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu