NRF2 is a potential biomarker for the evaluation of weaning-related oxidative stress in goat kids

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dc.authoridDalkiran, Sevda/0000-0002-5704-5774
dc.authoridOzkan, Huseyin/0000-0001-5753-8985
dc.authoridKaya, Ufuk/0000-0002-4805-0993
dc.contributor.authorOzkan, H.
dc.contributor.authorKaya, U.
dc.contributor.authorKaraaslan, I.
dc.contributor.authorDalkiran, S.
dc.contributor.authorCamdeviren, B.
dc.contributor.authorYuksel, M.
dc.contributor.authorYakan, A.
dc.date.accessioned2024-09-18T20:13:29Z
dc.date.available2024-09-18T20:13:29Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractWeaning stress is crucial threatening factor in animal breeding. The aim of this study was to investigate the effects of weaning to oxidative stress and stress status of goat kids at the molecular levels. In the study, blood samples were collected at the weaning process (7 days before weaning- Pre-W, Day of weaning- Day-W and 7 days after weaning- Post-W)from 24 healthy Damascus goats. Cortisol, MDA (Malondialdehyde), COX-2 (Cyclooxygenase-2), and NRF2 (Nuclear factor erythroid 2-related factor 2) proteins levels were investigated in plasma, while COX-2 and NRF2 genes expression levels were determined from leukocytes. Compared to Pre-W, COX-2 gene was upregulated almost 2-fold in Day-W. On the other hand, NRF2 gene expression levels were tended to upregulation in Day-W, and it was upregulated approximately 2-fold in Post-W. While MDA levels were gradually increased in the weaning process, the levels of COX-2 and NRF2 proteins showed similar changes with gene expression trends. Positive correlations were also found between cortisol and COX-2 and NRF-2 protein levels in plasma. It was thought that significant outputs gained in terms of MDA levels in plasma of kids at the weaning process. For the first time, determination of COX2 and NRF2 levels both mRNA and protein levels in the weaning process of goat kids were satisfactorily evaluated in this study. Particularly, NRF2 was found to have the potential to be a fundamental biomarker to assess the oxidative status of weaning kids.en_US
dc.description.sponsorshipScientific Research Council of Hatay Mustafa Kemal University [21.GAP.023]en_US
dc.description.sponsorshipThis study was funded by Scientific Research Council of Hatay Mustafa Kemal University with 21.GAP.023 project number.en_US
dc.identifier.doi10.12681/jhvms.28455
dc.identifier.endpage4932en_US
dc.identifier.issn1792-2720
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85148216756en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage4925en_US
dc.identifier.urihttps://doi.org/10.12681/jhvms.28455
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9221
dc.identifier.volume73en_US
dc.identifier.wosWOS:001059304000029en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherHellenic Veterinary Medical Socen_US
dc.relation.ispartofJournal of The Hellenic Veterinary Medical Societyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOX-2en_US
dc.subjectNRF2en_US
dc.subjectweaning stressen_US
dc.subjectoxidative stressen_US
dc.subjectDamascus goaten_US
dc.titleNRF2 is a potential biomarker for the evaluation of weaning-related oxidative stress in goat kidsen_US
dc.typeArticleen_US

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