Investigation of gastrointestinal injury-related biomarkers in dairy cattle with displaced abomasum

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dc.authoridERTURK, ALPER/0000-0002-4271-7953
dc.authoridSULU, KADIR/0000-0002-7246-8185
dc.authoridDURGUT, MURAT KAAN/0000-0002-4582-8536
dc.authoridGulersoy, Erdem/0000-0001-8511-0150
dc.authoridALKAN, Fahrettin/0000-0001-9637-1903
dc.authoridNASERI, AMIR/0000-0001-9140-5879
dc.contributor.authorIder, Merve
dc.contributor.authorYildiz, Ramazan
dc.contributor.authorNaseri, Amir
dc.contributor.authorGulersoy, Erdem
dc.contributor.authorAlkan, Fahrettin
dc.contributor.authorOk, Mahmut
dc.contributor.authorErturk, Alper
dc.date.accessioned2024-09-18T20:08:06Z
dc.date.available2024-09-18T20:08:06Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackgroundDisplaced abomasum (DA) is one of the most important metabolic disorders of dairy cattle. In DA, ischaemic damage may occur as a result of impaired perfusion due to abomasal displacement, which may result in gastrointestinal mucosal damage.ObjectiveInvestigation of gastrointestinal tissue damage in cattle with right displacement of the abomasum (RDA) and left displacement of the abomasum (LDA) using intestinal-related biomarkers.MethodsForty-eight DA (24 LDA, 24 RDA) and 15 healthy Holstein dairy cows were enrolled between March 2021 and July 2022. Serum biomarkers including gamma-enteric smooth muscle actin (ACTG-2), liver-fatty acid binding proteins (L-FABP), platelet activating factor (PAF), trefoil factor-3 (TFF-3), leptin, claudin-3 and interleukin-8 (IL-8) concentrations were measured from venous blood samples.ResultsL-FABP concentrations in the LDA group and TFF-3 concentrations in the RDA group were lower than in the control group. The leptin concentration of the RDA group was higher than that of the other groups. There was a negative correlation between lactate, leptin and IL-8 concentrations. There was a negative correlation between lactate and TFF-3, whereas leptin and lactate were positively correlated. Leptin was the more reliable biomarker for discriminating between RDA and LDA cases.ConclusionChanges in serum L-FABP, TFF-3 and leptin concentrations in cattle with DA may reflect acute intestinal injury and the subsequent repair phase. However, these biomarkers had poor diagnostic performance in discriminating between healthy and cattle with DA, while leptin emerged as the most useful marker in differentiating LDA from RDA cases. In this study, intestinal injury-related biomarkers were evaluated in serum samples from dairy cows with displaced abomasum (DA). Serum fatty acid binding proteins, trefoil factor-3 and leptin concentrations in cattle with DA indicate that intestinal damage develops in DA cases and the repair phase is activated against this damage.imageen_US
dc.identifier.doi10.1002/vms3.1292
dc.identifier.endpage2900en_US
dc.identifier.issn2053-1095
dc.identifier.issue6en_US
dc.identifier.pmid37776262en_US
dc.identifier.scopus2-s2.0-85173482857en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2893en_US
dc.identifier.urihttps://doi.org/10.1002/vms3.1292
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8633
dc.identifier.volume9en_US
dc.identifier.wosWOS:001075385700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofVeterinary Medicine and Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcattleen_US
dc.subjectleft displacement of abomasumen_US
dc.subjectleptinen_US
dc.subjectliver-fatty acid binding proteinsen_US
dc.subjectright displacement of abomasumen_US
dc.subjecttrefoil factor-3en_US
dc.titleInvestigation of gastrointestinal injury-related biomarkers in dairy cattle with displaced abomasumen_US
dc.typeArticleen_US

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