Effects of Oleuropein Oral Intake on Infected Fat Grafts: Experimental Study

Basit Öğe Kaydı
dc.authoridOkyay, Mehmet Fatih/0000-0002-7174-0917
dc.authoridBayraktar, Hamdullah Suphi/0000-0003-3400-9292
dc.contributor.authorBayraktar, Hamdullah Suphi
dc.contributor.authorOkyay, Mehmet Fatih
dc.date.accessioned2024-09-18T20:20:02Z
dc.date.available2024-09-18T20:20:02Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAim The aim of this study was to evaluate the effects of oleuropein oral intake on infected fat grafts and fat graft survival.Materials and Methods 32 Wistar albino rats were divided into four groups: 0. none treated, 1. serum oral intake, 2. antibiotic oral intake, and 3. oleuropein oral intake. The dorsal regions of the rats were separated into four quadrants as right and left cranial, and right and left caudal to determine each quadrant where fat grafts were placed. Right cranial and caudal quadrants were infected with the methicillin-susceptible Staphylococcus aureus (MSSA) strain. The left cranial and caudal quadrants were infected with the Pseudomonas aeruginosa strain. On the 7th day and end of the 3rd month, fibroblast density, inflammation, and fat survival were demonstrated immunohistochemically with FGF, CD68, and perilipin (PP), respectively.Results On the 7th day, for P. aureginosa-infected grafts, oleuropein was shown higher rates in CD68 and PP staining compared to the antibiotic group (p < 0.05, p < 0.001, respectively). At the end of the 3rd month, for P. aureginosa and S. aureus-infected grafts, the oleuropein group was demonstrated improved PP staining rates compared to the antibiotic group (p < 0.01, p < 0.01, respectively).Conclusion Oleuropein as a natural olive leaf extract with potent antioxidant, anti-inflammatory, and antimicrobial features is an alternative and supportive agent for both treatment and prophylaxis of surgical site infections like the antibiotics of chemical synthesis. P. aeruginosa and S. aureus surgical site infections could treat and prevent safely and effectively by oleuropein, particularly in early and late periods after surgery.No Level Assigned This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.en_US
dc.identifier.doi10.1007/s00266-023-03612-8
dc.identifier.issn0364-216X
dc.identifier.issn1432-5241
dc.identifier.pmid37658188en_US
dc.identifier.scopus2-s2.0-85169321540en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1007/s00266-023-03612-8
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10016
dc.identifier.wosWOS:001060190300002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAesthetic Plastic Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFat graft survivalen_US
dc.subjectSurgical site infectionen_US
dc.subjectOleuropeinen_US
dc.subjectStaphylococcus aureusen_US
dc.subjectPseudomonas aeruginosaen_US
dc.titleEffects of Oleuropein Oral Intake on Infected Fat Grafts: Experimental Studyen_US
dc.typeArticleen_US

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