The effect of caffeic acid phenethyl ester (CAPE) on histopathological changes in testicular ischemia-reperfusion injury

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dc.authoridGORUR, Sadik/0000-0002-3458-5428
dc.contributor.authorAtik, Esin
dc.contributor.authorGorur, Sadik
dc.contributor.authorKiper, Ahmet Namik
dc.date.accessioned2024-09-18T20:59:20Z
dc.date.available2024-09-18T20:59:20Z
dc.date.issued2006
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractTesticular torsion causes an enhanced formation of reactive oxygen species which contributes to the pathophysiology of ischemia-reperfusion injury in the testis. We evaluated here the effect of caffeic acid phenethyl ester (CAPE), a new antioxidant and anti-inflammatory agent on histopathological changes in testicular ischemia-reperfusion injury. Adult male Wistar rats were divided into six groups of five each: control group I (n = 5), sham operation group 2 (n = 5), torsion/detorsion (T/D) group 3 (it = 5), T/D + saline group 4 (n = 5), T/D + CAPE group 5 (n = 5) and T/D + CAPE group 6 (n = 5). Group I served to determine baseline values of histopathological parameters, group 2 animals that underwent sham operation served as a control, while groups 3-6 animals were subjected to left unilateral torsion (2 h) and detorsion (24 h) periods. All the groups were sacrified 24 h later except group 6. CAPE was injected 2 days with the same dose to the group 6 and it was sacrified 48 h later. One testis removed and fixed in Bouin's solution. After routine tissue processing myeloperoxidase (MPO) and inducible nitric oxide synthase (iNOS) immunohistochemical methods were studied from paraffin embedded tissues. Treating rats with CAPE (applied at 10 mu mol/kg, 30 min prior to T/D) attenuated the testicular injury and as well as the tissue levels of MPO. At the same time testis tissue showed a decrease in iNOS activity. Our results suggest that CAPE treatment have a protective role on testicular T/D and this effect may be due to inhibiting the neutrophil mediated cellular injury. (c) 2006 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.phrs.2006.06.005
dc.identifier.endpage297en_US
dc.identifier.issn1043-6618
dc.identifier.issue4en_US
dc.identifier.pmid16887363en_US
dc.identifier.scopus2-s2.0-33747166515en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage293en_US
dc.identifier.urihttps://doi.org/10.1016/j.phrs.2006.06.005
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12522
dc.identifier.volume54en_US
dc.identifier.wosWOS:000241250100007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Ltd Elsevier Science Ltden_US
dc.relation.ispartofPharmacological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecttesticular ischemia-reperfusionen_US
dc.subjectnitric oxideen_US
dc.subjectmyeloperoxidaseen_US
dc.subjectcaffeic acid phenethyl esteren_US
dc.titleThe effect of caffeic acid phenethyl ester (CAPE) on histopathological changes in testicular ischemia-reperfusion injuryen_US
dc.typeArticleen_US

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