Analysis of the effects of subthalamic nucleus deep brain stimulation on somatosensation in Parkinson's disease patients

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dc.authoridYILMAZ, Atilla/0000-0002-1081-3545
dc.authoridDOGRU HUZMELI, Esra/0000-0002-7025-8192
dc.contributor.authorHuzmeli, Esra Dogru
dc.contributor.authorYilmaz, Atilla
dc.contributor.authorOkuyucu, Esra
dc.date.accessioned2024-09-18T20:15:02Z
dc.date.available2024-09-18T20:15:02Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective Despite the subthalamic nucleus (STN) deep brain stimulation (DBS) is a treatment commonly used to ameliorate the motor symptoms of Parkinson's disease (PD), its effects on somatosensation is unclear. The purpose of this study was to investigate the potential effects of DBS on temperature, proprioceptive, tactile, exteroceptive, pain and cortical sensations, and odor identification in PD patients. Methods The study included 14 patients (with a mean age of 59.78 +/- 11.03 years; range, 44-70 years) with idiopathic PD who underwent DBS surgery for movement disorders caused by PD at the same Neurosurgery Department. All patients were tested while DBS was turned on (DBS-ON) and off (DBS-OFF). To clearly observe the effect of removing stimulation off, DBS devices were turned off by experimental clinical personnel for a minimum duration of 30 min prior to examination. Temperature, proprioceptive, tactile, exteroceptive, pain and cortical sensations, and odor identification were examined. Results We found that two-point discrimination was significantly lower during DBS-ON than DBS-OFF (p = 0.031). Tactile sensation and kinesthesia deviation degree were lower during DBS-ON than DBS-OFF, but were non-significant (p > 0.05). The number of correct answers on an assessment of graphesthesia was higher during DBS-ON, but was non-significant as well (p > 0.05). Odor identification was better during DBS-OFF. Conclusions DBS may have an effective role to improve somatosensation and DBS-related benefits may not be explained by improvements in motor function alone, but rather by enhanced somatosensory processing. Further studies with larger study groups are needed.en_US
dc.identifier.doi10.1007/s10072-019-04168-9
dc.identifier.endpage931en_US
dc.identifier.issn1590-1874
dc.identifier.issn1590-3478
dc.identifier.issue4en_US
dc.identifier.pmid31845044en_US
dc.identifier.scopus2-s2.0-85076604427en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage925en_US
dc.identifier.urihttps://doi.org/10.1007/s10072-019-04168-9
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9405
dc.identifier.volume41en_US
dc.identifier.wosWOS:000526087000022en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer-Verlag Italia Srlen_US
dc.relation.ispartofNeurological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDeep brain stimulationen_US
dc.subjectSubthalamic nucleusen_US
dc.subjectTwo-point discriminationen_US
dc.subjectNon-motor symptom scaleen_US
dc.subjectOdor identificationen_US
dc.subjectKinesthesiaen_US
dc.titleAnalysis of the effects of subthalamic nucleus deep brain stimulation on somatosensation in Parkinson's disease patientsen_US
dc.typeArticleen_US

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