Protective effects of tempol in an experimental ovarian ischemia-reperfusion injury model in female Wistar albino rats

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dc.contributor.authorPinar, Neslihan
dc.contributor.authorKarapinar, Oya Soylu
dc.contributor.authorOzcan, Oguzhan
dc.contributor.authorDogan, Esin Atik
dc.contributor.authorBayraktar, Suphi
dc.date.accessioned2024-09-18T20:53:01Z
dc.date.available2024-09-18T20:53:01Z
dc.date.issued2017
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the antioxidant effects of tempol on ovarian ischemia-reperfusion (I/R) injury in rats. Forty female Wistar albino rats were randomly divided into 5 groups: Group I, sham; Group II, ischemia (I); Group III, I/R; Group IV, I/R + tempol 30 mg/kg i.p; Group V, I/R + tempol 50 mg/kg i.p. Oxidative stress index (OSI) was significantly higher in the ischemia group and the I/R group than in the sham group. Catalase levels were significantly lower in the I/R group than in the I/R + tempol 30 mg/kg i.p. and the I/R + tempol 50 mg/kg i.p. groups. Glutathione peroxidase levels were lower in the I/R group than in the I/R + tempol 30 mg/kg i.p. and the I/R + tempol 50 mg/kg i.p. groups. MDA levels were significantly lower in the I/R + tempol 30 mg/kg i.p. group and the I/R + tempol 50 mg/kg i.p. group than in the I/R group. The levels of the histopathological parameters were significantly decreased in the I/R + tempol 50 mg/kg i.p. group compared with the I/R group. Tempol can be used for reducing ovarian I/R injury.en_US
dc.identifier.doi10.1139/cjpp-2016-0309
dc.identifier.endpage865en_US
dc.identifier.issn0008-4212
dc.identifier.issn1205-7541
dc.identifier.issue7en_US
dc.identifier.pmid28423286en_US
dc.identifier.scopus2-s2.0-85021841544en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage861en_US
dc.identifier.urihttps://doi.org/10.1139/cjpp-2016-0309
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11539
dc.identifier.volume95en_US
dc.identifier.wosWOS:000404738500011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCanadian Science Publishingen_US
dc.relation.ispartofCanadian Journal of Physiology and Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectovarian ischemia-reperfusionen_US
dc.subjecttempolen_US
dc.subjectoxidative stressen_US
dc.titleProtective effects of tempol in an experimental ovarian ischemia-reperfusion injury model in female Wistar albino ratsen_US
dc.typeArticleen_US

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