Beneficial effects of rolipram, a phosphodiesterase 4 specific inhibitor, on testicular torsion-detorsion injury in rats

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dc.authoridDundar Yenilmez, Ebru/0000-0002-5519-3773
dc.contributor.authorAbat, Deniz
dc.contributor.authorBayazit, Yildirim
dc.contributor.authorAcikalin, Arbil
dc.contributor.authorDaglioglu, Kenan
dc.contributor.authorYenilmez, Ebru Dundar
dc.contributor.authorAltunkol, Adem
dc.contributor.authorErdogan, Seyda
dc.date.accessioned2024-09-18T20:28:04Z
dc.date.available2024-09-18T20:28:04Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIntroduction: The aim of the study is to investigate the effect of Rolipram, a selective phosphodiesterase 4 inhibitor, on testicular torsion - detorsion injury. Methods: Sixty young male rats were divided into five groups. In each group, the right testes of six rats were removed four hours after detorsion for biochemical analysis, and the right testes of the remaining six rats were removed 24 h after detorsion for pathological analysis. In group 1 (sham-operated) right orchiectomy was performed without torsion, and right testes were sent to the laboratory for biochemical and pathologic analyses. In group 2 (control) torsion was applied to the right testes for 60 min, and detorsion was performed without the administration of Rolipram. In group 3 torsion was applied to the right testes for 60 min. 1 mg/kg Rolipram was administered 30 min before detorsion. In group 4 torsion was applied to the right testes for 60 min, and 1 mg/kg Rolipram was administered during detorsion. In group 5 torsion was applied to the right testes for 60 min. 1 mg/kg Rolipram was administered 30 min after detorsion. The malondialdehyde and nitric oxide levels were determined. The rates of necrosis and apoptosis were evaluated by histopathological examination. Results: The level of malondialdehyde was higher in the torsioned groups (Group 2, 3, 4. 5) than that in group 1 (p = 0.004). There was no statistically significant difference between the groups regarding the level of nitric oxide (p = 0.182). Apoptosis was higher in groups 2, 3 and 4 than in group 1; however, apoptosis was similar in group 1 and group 5 (p = 0.122). The level of necrosis in group 1 was similar to that in groups 4 and 5 (p = 0.194 and p = 0.847, respectively). Conclusion: We suggest that the administration of Rolipram can decrease the rate of necrosis and apoptosis in testicular ischaemia-reperfusion injury. (C) 2018 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipAcademic Research Projects Unit of the University of Cukurova [TF2010BAP17]en_US
dc.description.sponsorshipThis study was supported by the Academic Research Projects Unit of the University of Cukurova with the grant number TF2010BAP17.en_US
dc.identifier.doi10.1016/j.jpedsurg.2018.04.013
dc.identifier.endpage2265en_US
dc.identifier.issn0022-3468
dc.identifier.issn1531-5037
dc.identifier.issue11en_US
dc.identifier.pmid29773452en_US
dc.identifier.startpage2261en_US
dc.identifier.urihttps://doi.org/10.1016/j.jpedsurg.2018.04.013
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10713
dc.identifier.volume53en_US
dc.identifier.wosWOS:000446881300034en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofJournal of Pediatric Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIschaemia/reperfusion injuryen_US
dc.subjectReactive oxygen speciesen_US
dc.subjectTestisen_US
dc.titleBeneficial effects of rolipram, a phosphodiesterase 4 specific inhibitor, on testicular torsion-detorsion injury in ratsen_US
dc.typeArticleen_US

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