Effects of Desflurane and Isoflurane on Postanaesthetic Recovery Characteristics with Hepatic and Renal Functions in Dogs

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dc.contributor.authorAltug, M. E.
dc.contributor.authorGonenci, R.
dc.contributor.authorDurgut, R.
dc.contributor.authorKarasu, A.
dc.contributor.authorAbdulhayoglu, B.
dc.date.accessioned2024-09-18T20:15:06Z
dc.date.available2024-09-18T20:15:06Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of the study, was to investigate the effects of desflurane and isoflurane on postanaesthetic recovery characteristics with hepatic and renal functions in dogs. Sixteen adult mongrel dogs of both sexes weighing between 16-21 kg were equally divided into 2 groups. Anaesthesia was induced with 0.3 mg kg(-1) midazolam and 10 mg kg(-1) thiopental intravenously. Maintenance of anaesthesia was continued with 7.2-8% desflurane or 1.3-1.5% isoflurane. Heart and respiration rates, arterial haemoglobin oxygen saturation and rectal temperatures were monitored before, during, 1 h and 1 day after anaesthesia periodically and postanaesthetic recovery score times were also observed. Serum alanine aminotransferase, aspartate aminotransferase, gamma-glutamyltransferase, blood urea nitrogen, total bilirubin and creatinine levels were measured in venous blood samples. Postanaesthetic recovery scores including time to standing, time to reaching sternal recumbency, eye opening and time to extubation were found shorter in desflurane group than isoflurane group (p<0.05). Alanine aminotransferase, aspartate aminotransferase and gamma-glutamyltransferase activities were non-significantly increased in the isoflurane group and there were no change between groups. Total bilirubin and creatinine levels were non-significantly decreased, blood urea nitrogen levels were non-significantly increased within normal range during and after the anaesthesia in both groups. The present study reveals 2 important results. Firstly, desflurane provided faster anaesthetic induction, recovery with less excitation and rapid recovery times (p<0.05) and the dogs stood up in shorter time than those of isoflurane. Secondly, this study indicates that both volatile agents have no harmful side effects on renal and hepatic functions in dogs.en_US
dc.description.sponsorshipMustafa Kemal University Scientific Projects Support Foundation [02 G 0203]en_US
dc.description.sponsorshipThe authors wish to acknowledge Mustafa Kemal University Scientific Projects Support Foundation for supporting this research (Project number: 02 G 0203).en_US
dc.identifier.endpage357en_US
dc.identifier.issn1680-5593
dc.identifier.issn1993-601X
dc.identifier.issue2en_US
dc.identifier.startpage350en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9454
dc.identifier.volume8en_US
dc.identifier.wosWOS:000264104700030en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherMedwell Onlineen_US
dc.relation.ispartofJournal of Animal and Veterinary Advancesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDesfluraneen_US
dc.subjectisofluraneen_US
dc.subjectdogen_US
dc.subjectpostanaesthetic recovery scoresen_US
dc.subjectrenal and hepatic functionsen_US
dc.titleEffects of Desflurane and Isoflurane on Postanaesthetic Recovery Characteristics with Hepatic and Renal Functions in Dogsen_US
dc.typeArticleen_US

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