Biochemical Evaluation of the Effects of Concentrated Growth Factor Liquid on Osseointegration: A Split-Mouth Design Study

Basit Öğe Kaydı
dc.contributor.authorAtilgan, Muhammet
dc.contributor.authorArpag, Osman Fatih
dc.contributor.authorOzcan, Oguzhan
dc.contributor.authorKacmaz, Filiz
dc.date.accessioned2024-09-18T20:11:44Z
dc.date.available2024-09-18T20:11:44Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose: To investigate cytokine levels in peri-implant crevicular fluid and thus evaluate the effects of concentrated growth factor (CGF) on osseointegration. Materials and Methods: A total of 40 mandibular implants were symmetrically placed in a group of 20 systemically healthy patients enrolled in the study. In each patient, one implant wetted with liquid infiltrated from fibrin matrix was placed in the test side (Group L), and the other implant was placed in the control side without the application of any material (Group C). Peri-implant crevicular fluid was collected at 2, 4, and 12 weeks later. Marginal bone loss was measured with panoramic radiographs taken immediately after implant placement and at 12 weeks. Resonance frequency analysis (RFA) of the implants was performed intraoperatively and at 4 and 12 weeks. Results: Stability values of the implants in the CGF liquid-treated sites were higher than those of the control group at week 12 (P =.005). There was no statistically significant difference between the two groups in terms of marginal bone loss (MBL). Group L showed increased levels of tumor necrosis factor alpha (TNF-a) and receptor activator of nuclear factor kappa-B ligand (RANKL) at 2 and 4 weeks. Also, levels of osteoprotegerin (OPG) were higher in Group L at week 4 compared to Group C (P =.033). Conclusions: The increased TNF-a, RANKL, and OPG levels in this study demonstrate that CGF liquid can be used to accelerate peri-implant bone remodeling in the early phase of osseointegration. Int J Oral Maxillofac Implants 2023:38:1182-1190. doi: 10.11607/jomi.10066en_US
dc.description.sponsorshipCoordinatorship of Scientific Research Projects from Hatay Mustafa Kemal University [20, U.002]en_US
dc.description.sponsorshipThe authors declare no conflict of interest. Thanks are expressed to Dr Emre Dirican for his help with the statistical analysis of the data in the study. Moreover, we would like to thank Dr Bunyamin Guzel, a specialist in the field of periodontology, for his contributions as a blinded examiner. This study was supported by the Coordinatorship of Scientific Research Projects from Hatay Mustafa Kemal University (project no. 20.U.002).en_US
dc.identifier.doi10.11607/jomi.10066
dc.identifier.endpage1190en_US
dc.identifier.issn0882-2786
dc.identifier.issn1942-4434
dc.identifier.issue6en_US
dc.identifier.pmid38085750en_US
dc.identifier.scopus2-s2.0-85179642185en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1182en_US
dc.identifier.urihttps://doi.org/10.11607/jomi.10066
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9042
dc.identifier.volume38en_US
dc.identifier.wosWOS:001171281500013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherQuintessence Publishing Co Incen_US
dc.relation.ispartofInternational Journal of Oral & Maxillofacial Implantsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectConcentrated growth factoren_US
dc.subjectperi-implant crevicular fluiden_US
dc.subjectcytokineen_US
dc.subjectosseointegrationen_US
dc.titleBiochemical Evaluation of the Effects of Concentrated Growth Factor Liquid on Osseointegration: A Split-Mouth Design Studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu