An efficient synthesis of novel di-heterocyclic benzazole derivatives and evaluation of their antiproliferative activities

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dc.authoridHAJ ERSAN, RONAK/0000-0001-6651-5910
dc.contributor.authorAlgul, Oztekin
dc.contributor.authorErsan, Ronak Haj
dc.contributor.authorAlagoz, Mehmet Abdullah
dc.contributor.authorDuran, Nizami
dc.contributor.authorBurmaoglu, Serdar
dc.date.accessioned2024-09-18T20:15:13Z
dc.date.available2024-09-18T20:15:13Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractA series of unsymmetrical nine di-heterocyclic compounds of benzazole derivatives were synthesized at one step via cyclization reaction. The compounds evaluated forin vitrocytotoxic activity against A549, A498, HeLa, and HepG2 cancer cell lines. The biological evaluation results show that23, 26and29exhibit better activity against HepG2 and HeLa cancer cell lines. Compound23also showed good activity against A549, and A498 cancer cell lines. The analogs were further performed molecular docking studies against human cytochrome P450 2C8 monooxygenase enzyme, calculated some theoretical quantum parameters, ADMET descriptor and molecular electrostatic potential analysis. The strategy applied in this research work may act as a perspective for the rational design of potential anticancer drugs. Communicated by Ramaswamy H. Sarmaen_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [115S190]; Mersin University [BAP-SBE-2018-1-TP3-2911]en_US
dc.description.sponsorshipWe thank the Scientific and Technological Research Council of Turkey (TUBITAK Grant Number: 115S190) and Mersin University for their financial support (BAP-SBE-2018-1-TP3-2911).en_US
dc.identifier.doi10.1080/07391102.2020.1803966
dc.identifier.endpage6938en_US
dc.identifier.issn0739-1102
dc.identifier.issn1538-0254
dc.identifier.issue18en_US
dc.identifier.pmid32772845en_US
dc.identifier.scopus2-s2.0-85089254969en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage6926en_US
dc.identifier.urihttps://doi.org/10.1080/07391102.2020.1803966
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9520
dc.identifier.volume39en_US
dc.identifier.wosWOS:000557611000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal of Biomolecular Structure & Dynamicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDi-heterocyclic structureen_US
dc.subjectbenzimidazoleen_US
dc.subjectbenzothiazoleen_US
dc.subjectbenzoxazoleen_US
dc.subjectbenzazoleen_US
dc.subjectpolyphosphoric aciden_US
dc.subjectantiproliferative activityen_US
dc.subjectmolecular dockingen_US
dc.subjectADMETen_US
dc.titleAn efficient synthesis of novel di-heterocyclic benzazole derivatives and evaluation of their antiproliferative activitiesen_US
dc.typeArticleen_US

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