Inhibitory effects of acetylsalicylic acid on exocrine pancreatic carcinogenesis

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dc.authoridYILDIZ, Hasan/0000-0001-5486-4005
dc.contributor.authorYildiz, H.
dc.contributor.authorOztas, H.
dc.contributor.authorYildiz, D.
dc.contributor.authorKoc, A.
dc.contributor.authorKalipci, E.
dc.date.accessioned2024-09-18T19:48:02Z
dc.date.available2024-09-18T19:48:02Z
dc.date.issued2013
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractWe investigated short (6 months) and long (12 months) term inhibitory effects of low (200 ppm) and high (400 ppm) dosages of acetylsalicylic acid (aspirin) on exocrine pancreatic carcinogenesis. It is known that exocrine pancreatic carcinogenesis can be detected by the presence of atypical acinar cell foci (AACF) in pancreas. We investigated possible inhibitory effects of acetylsalicylic acid in an azaserine-treated rat model. AACF were produced in rats by injection with azaserine according to previous studies. Our findings showed that the number, volume and diameter of pancreatic AACF were reduced after acetylsalicylic acid application. These observations suggest that acetylsalicylic acid may exert a protective effect against neoplastic development of pancreatic acinar cells in azaserine injected rats. Our findings corroborate reports in the literature concerning the effects of aspirin in reducing neoplastic development.en_US
dc.identifier.doi10.3109/10520295.2012.758779
dc.identifier.endpage137en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue3-4en_US
dc.identifier.pmid23331184en_US
dc.identifier.scopus2-s2.0-84876490364en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage132en_US
dc.identifier.urihttps://doi.org/10.3109/10520295.2012.758779
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7320
dc.identifier.volume88en_US
dc.identifier.wosWOS:000321904500002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectacetylsalicylic aciden_US
dc.subjectatypical acinar cell focien_US
dc.subjectazaserinen_US
dc.subjectquantitative analysisen_US
dc.subjectratsen_US
dc.titleInhibitory effects of acetylsalicylic acid on exocrine pancreatic carcinogenesisen_US
dc.typeReview Articleen_US

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