Investigation of free radical scavenging enzyme activities and lipid peroxidation in liver tissue of zinc deficient rats

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dc.contributor.authorKaya, Hasan
dc.contributor.authorTaysi, Seyithan
dc.contributor.authorKaya, Abdullah
dc.contributor.authorBoyuk, Abdullah
dc.contributor.authorDursun, Hakan
dc.contributor.authorIslamoglu, Yahya
dc.contributor.authorTastekin, Didem
dc.date.accessioned2024-09-18T20:29:35Z
dc.date.available2024-09-18T20:29:35Z
dc.date.issued2008
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the lipid peroxidation and free radical scavenging enzyme activities in liver tissue of zinc (Zn)-deficient rats and investigate relationship among these parameters in either group. 16 Male rats with a weight of 35-40 g were used for the experiment. The rats were divided into control (n = 8) and Zn-deficient groups. After 4 weeks of feeding, the rats were killed by cervical dislocation and liver tissues were removed. Biochemical measurements in liver tissue were carried out using a spectrophotometer. Catalase, glutathione peroxidase, glutathione reductase, glutathione S transferase activities, total (enzymatic plus non-enzymatic) superoxide scavenger activity, superoxide dismutase, non-enzymatic superoxide scavenger activity, superoxide dismutase activities and Zn level in the Zn-deficient group were significantly lower than those of the control group, whereas malondialdehyde level was significantly higher than those of the control group. Slightly increased non-enzymatic superoxide scavenger activity was not significantly different from the controls. The results obtained in this study demonstrate that Zn-deficiency causes a decrease in antioxidant defence system and an increase in oxidative stress in liver tissue in rats.en_US
dc.identifier.endpage1074en_US
dc.identifier.issn0970-7077
dc.identifier.issn0975-427X
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-53949116558en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1068en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10954
dc.identifier.volume20en_US
dc.identifier.wosWOS:000259602200037en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAsian Journal Of Chemistryen_US
dc.relation.ispartofAsian Journal of Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectlipid peroxidationen_US
dc.subjectmalondialdehydeen_US
dc.subjectantioxidant enzymesen_US
dc.subjectzincen_US
dc.subjecttrace elementen_US
dc.subjectfree radicalsen_US
dc.titleInvestigation of free radical scavenging enzyme activities and lipid peroxidation in liver tissue of zinc deficient ratsen_US
dc.typeArticleen_US

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