A new therapeutic approach for the treatment of cutaneous leishmaniasis: Photothermal application of macrophage-specific antibody binding graphene oxide nanoparticles

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dc.contributor.authorOzpinar, Necati
dc.contributor.authorPolat, Zubeyda Akin
dc.date.accessioned2024-09-18T20:13:40Z
dc.date.available2024-09-18T20:13:40Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground & objectives: Cutaneous leishmaniasis (CL) is a zoonotic and anthropogenic protozoal disease. We aimedto develop a new therapeutic approach for the treatment of CL. Methods: BALB/c mice have infected L. major amastigotes from their footpads. Twenty-one days later after injection, the animals were divided into three control and three experimental groups. The intralesional injection of graphene oxide and photothermal application (GO+PA) were applied to the first experimental group (Group 1); graphene oxide modified with a macrophage-specific antibody and photothermal application (MSA+GO+PA) were applied to the second experimental group (Group 2), and the photothermal application (PA) was applied to the third experimental group (Group 3). Miltefosine was administered orally to the first control group (Group 4); the second control group that is not treated was assigned as the positive control (Group 5) and the third control group was assigned as the negative control (Group 6). Lesions were examined (erythema and edema) after the 5th day and 10th of the treatment, clinically. On the 10th day of the treatment, the level of TNF-alpha, IL-1, IL-6, and IFN-gamma were detected histopathologically and immunohistochemically. Results: In the 5th day of the treatment it was observed that 50% of the animals were completely treated with Group 2, and in the 10th day, the ration raised to 75%. Interpretation & conclusion: We showed a novel application to treat CL by using MSA modified GO and PA within 10 days. According to our study outcomes, this application could be a new treatment approach for CL cure.en_US
dc.description.sponsorshipCumhuriyet University Scientific Research Projects Unit [T-682]en_US
dc.description.sponsorshipWe want to thank Celal Bayar University Parasites Bank and Air Liquide, Prof. Dr. Reyhan Egilmez for her contribution in histopathological, immunofluorescence and immunohistochemical studies; and Assoc. Dr. Murat Erdem for his contribution to FT-IR and elemental analy-sis. This study was funded by the Cumhuriyet University Scientific Research Projects Unit (T-682)en_US
dc.identifier.doi10.4103/0972-9062.313974
dc.identifier.endpage355en_US
dc.identifier.issn0972-9062
dc.identifier.issue4en_US
dc.identifier.pmid34856715en_US
dc.identifier.scopus2-s2.0-85117941949en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage347en_US
dc.identifier.urihttps://doi.org/10.4103/0972-9062.313974
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9317
dc.identifier.volume57en_US
dc.identifier.wosWOS:000713310100009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofJournal of Vector Borne Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCutaneous Leishmaniasisen_US
dc.subjectBALB/cen_US
dc.subjectNanoparticleen_US
dc.subjectGraphene oxideen_US
dc.subjectPhototherapyen_US
dc.titleA new therapeutic approach for the treatment of cutaneous leishmaniasis: Photothermal application of macrophage-specific antibody binding graphene oxide nanoparticlesen_US
dc.typeArticleen_US

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