Effects of Hypericum perforatum on the healing of xenografts: a histomorphometric study in rabbits

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dc.authoridAltan, Ahmet/0000-0003-2041-6364
dc.contributor.authorDamlar, I.
dc.contributor.authorArpag, O. F.
dc.contributor.authorTatli, U.
dc.contributor.authorAltan, A.
dc.date.accessioned2024-09-18T20:27:55Z
dc.date.available2024-09-18T20:27:55Z
dc.date.issued2017
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate effects of the Hypericum perforatum (St John's Wort) on bone healing in rabbit calvarium. Ten male New Zealand rabbits each had three bicortical defects made in the calvarial bones, which were filled with xenograft, xenograft + H perforatum oil extract, and autogenous graft. Four weeks postoperatively all rabbits were killed and the bony defects examined histomorphometrically. Tissue compartments including new bone (p < 0.001), marrow space (p < 0.001), and residual bone grafts (p = 0.014) differed significantly among groups. The volume of residual graft was significantly decreased in the xenograft/H perforatum group compared with those with xenografts alone (p = 0.0147). The differences in microarchitectural variables of de novo bone formation were also significant (trabecular thickness (p < 0.001), trabecular width (p < 0.001), trabecular separation (p = 0.001). There were no significant differences in node: terminus ratio between the xenograft/H perforatum group and the other two groups. However, the difference in node: terminus ratio between the autogenous graft and xenograft group was significant (p = 0.001) Oil extracts of H perforatum improved bony healing in defects filled with bovine-derived xenografts. (C) 2016 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipMustafa Kemal University Scientific Research Coordination Unit [10422]en_US
dc.description.sponsorshipThe present study was supported by Mustafa Kemal University Scientific Research Coordination Unit (Project number: 10422)en_US
dc.identifier.doi10.1016/j.bjoms.2016.12.003
dc.identifier.endpage387en_US
dc.identifier.issn0266-4356
dc.identifier.issn1532-1940
dc.identifier.issue4en_US
dc.identifier.pmid28007487en_US
dc.identifier.scopus2-s2.0-85008439820en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage383en_US
dc.identifier.urihttps://doi.org/10.1016/j.bjoms.2016.12.003
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10602
dc.identifier.volume55en_US
dc.identifier.wosWOS:000404410500014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofBritish Journal of Oral & Maxillofacial Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHypericum Perforatumen_US
dc.subjectXenogreften_US
dc.subjectBone Healingen_US
dc.titleEffects of Hypericum perforatum on the healing of xenografts: a histomorphometric study in rabbitsen_US
dc.typeArticleen_US

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