Nasobiliary drainage for benign recurrent intrahepatic cholestasis in patients refractory to standard therapy

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dc.authorscopusid24470317500
dc.authorscopusid58602450200
dc.authorscopusid16028620600
dc.authorscopusid57193009316
dc.authorscopusid25641781500
dc.authorscopusid35796175800
dc.authorscopusid7004054394
dc.contributor.authorYakar, Tolga
dc.contributor.authorDemir, Mehmet
dc.contributor.authorGokturk, Huseyin S.
dc.contributor.authorKanat, Ayse G. Unler
dc.contributor.authorParlakgumus, Alper
dc.contributor.authorOzer, Birol
dc.contributor.authorSerin, Ender
dc.date.accessioned2024-09-19T15:49:53Z
dc.date.available2024-09-19T15:49:53Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose: Benign recurrent intrahepatic cholestasis (BRIC) is characterized by episodic cholestasis and pruritus without anatomical obstruction. The aim of this study was to evaluate the safety and efficacy of nasobiliary drainage (NBD) in patients with BRIC refractory to medical therapy and to determine whether the use of NBD prolongs the episode duration. Methods: This was a multicenter retrospective study consisting of 33 patients suffering from BRIC. All patients were administrated medical treatment and 16 patients who were refractory to standard medical therapies improved on treatment with temporary endoscopic NBD. Duration of treatment response and associated complications were analyzed. Results: Sixteen patients (43% females) underwent 25 NBD procedures. The median duration of NBD was 17 days. There were significant improvements in total and direct bilirubin and alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma-glutamyl transpeptidase on the 3rd day of NBD. Longer clinical remission was monitored in the NBD group. Post-endoscopic retrograde cholangiopancreatography pancreatitis was observed in one of 16 cases. Conclusion: NBD effectively eliminates BRIC in all patients and improves biomarkers of cholestasis. It can be suggested that patients with attacks of BRIC can be treated with temporary endoscopic NBD; however, the results of this study should be confirmed by prospective studies in the future. © 2016 CIM.en_US
dc.identifier.endpageS172en_US
dc.identifier.issn0147-958X
dc.identifier.issue6en_US
dc.identifier.pmid27917812en_US
dc.identifier.scopus2-s2.0-85009989787en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageS164en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/15474
dc.identifier.volume39en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherThe Canadian Society for Clinical Investigationen_US
dc.relation.ispartofClinical and Investigative Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleNasobiliary drainage for benign recurrent intrahepatic cholestasis in patients refractory to standard therapyen_US
dc.typeArticleen_US

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