Protective effects of silymarin on methotrexate-induced damages in rat testes

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dc.authoridUSLU, Baris Atalay/0000-0003-1866-932X
dc.authoridYENER, Zabit/0000-0002-6365-5843
dc.contributor.authorYaman, Turan
dc.contributor.authorUyar, Ahmet
dc.contributor.authorKaya, Mehmet Salih
dc.contributor.authorKeles, Omer Faruk
dc.contributor.authorUslu, Baris Atalay
dc.contributor.authorYener, Zabit
dc.date.accessioned2024-09-18T20:57:03Z
dc.date.available2024-09-18T20:57:03Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe present study aimed to investigate the protective effects of silymarin (SMN), an antioxidant, on methotrexate (MTX)-induced damage in rat testes. Thirty-two Wistar albino rats were divided into four groups (n = 8): control, MTX (20 mg/kg, i.p. on days 1 and 5), SMN (200 mg/kg, orally), and MTX + SMN (20 mg/kg, i.p. on days 1 and 5 and SMN 200 mg/kg orally) groups. At the end of the 6-week trial period, histopathological, immunohistochemical, biochemical, and spermatological analyses were performed on testes tissues. Histopathologically, MTX-induced damage, including depletion of germ cell and loos of spermatozoa, was significantly improved with SMN treatment. Immunohistochemically, the immunoreactivity of glutathione peroxidase 1 (GPx1) and manganese superoxide dismutase 2 (SOD2) were detected more intensely in the MTX + SMN group than in the MTX group. Biochemical examinations revealed that SMN supplementation decreased the lipid peroxidation and increased enzymatic antioxidants in the SMN-treated rats. Spermatologically, significant differences were found in the density, motility, dead-to-live sperm ratio, and abnormal sperm rate in the MTX + SMN group compared to the MTX group. In conclusion, SMN seems to have protective effects as an antioxidant against MTX-induced damage in rat testes.en_US
dc.identifier.doi10.1590/s2175-97902018000117529
dc.identifier.issn1984-8250
dc.identifier.issn2175-9790
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85048554670en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1590/s2175-97902018000117529
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12264
dc.identifier.volume54en_US
dc.identifier.wosWOS:000435137600001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniv Sao Paulo, Conjunto Quimicasen_US
dc.relation.ispartofBrazilian Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSilymarin/effectsen_US
dc.subjectMethotrexate/Testes/induced damagesen_US
dc.subjectGPx1en_US
dc.subjectSOD2en_US
dc.subjectPathologyen_US
dc.titleProtective effects of silymarin on methotrexate-induced damages in rat testesen_US
dc.typeArticleen_US

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