Inhibitory effect of stinging nettle (Urtica dioica L.) extract on body weight gain in rats on a high-fat diet

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dc.contributor.authorKacak, Kenan
dc.contributor.authorYaman, Turan
dc.contributor.authorUyar, Ahmet
dc.contributor.authorKomuroglu, Ahmet Ufuk
dc.date.accessioned2024-09-18T20:26:45Z
dc.date.available2024-09-18T20:26:45Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIntroduction: The leaves and seeds of Urtica dioica (UD) are used in folk treatments for many diseases. Anticarcinogenic, anti-inflammatory, antioxidant, and antiallergenic properties of UD have been reported. Aim: To uncover the effects of nettle seed (Urtica dioica; UD) extract on body weight gain in rats on a high -fat diet (HFD). Material and methods: Male Wistar albino rats (n = 32) were divided into 4 groups, comprising a control group, a group that received a HFD (HFD group), a group that received UD extracts (UD group), and a group that received a HFD as well as UD extracts (HFD + UD group). UD extracts were given a daily dose of 300 mg/kg of body weight orally for 75 days. Results: The HFD led to weight gain that was partially moderated by the UD extract. Histopathological findings in the HFD + UD group were uniformly significantly lower than those in the HFD group. Serum alanine transaminase, alanine aminotransferase, triglyceride, and low -density lipoprotein levels were significantly higher in the HFD group than in the HFD + UD group, and the HDL levels were lower in the HFD group than in the control group and the HFD + UD group. Conclusions: The cholesterol levels were discovered to be highest in the HFD + UD group. Therefore, it was concluded that the UD extract did not completely protect the rats against body weight gain.en_US
dc.description.sponsorshipVan Yuzuncu Yil University Scientific Research Projects Foundation [TYL-2018-7381]en_US
dc.description.sponsorshipThis study was funded by the Van Yuzuncu Yil University Scientific Research Projects Foundation (Grant number TYL-2018-7381) . This study was prepared from Kenan KACAK's master's thesisen_US
dc.identifier.doi10.5114/pg.2023.130142
dc.identifier.endpage32en_US
dc.identifier.issn1895-5770
dc.identifier.issn1897-4317
dc.identifier.issue1en_US
dc.identifier.pmid38571539en_US
dc.identifier.scopus2-s2.0-85189296592en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage23en_US
dc.identifier.urihttps://doi.org/10.5114/pg.2023.130142
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10518
dc.identifier.volume19en_US
dc.identifier.wosWOS:001197272000007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofGastroenterology Review-Przeglad Gastroenterologicznyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecthistopathologyen_US
dc.subjectbody weight gainen_US
dc.subjectUrtica dioicaen_US
dc.titleInhibitory effect of stinging nettle (Urtica dioica L.) extract on body weight gain in rats on a high-fat dieten_US
dc.typeArticleen_US

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