Immunohistochemical analysis of p16 expression in uterine smooth muscle tumors

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dc.authoridTOPRAK, SERHAT/0000-0003-4136-0523
dc.contributor.authorHakverdi, S.
dc.contributor.authorGungoren, A.
dc.contributor.authorYaldiz, M.
dc.contributor.authorHakverdi, A. U.
dc.contributor.authorToprak, S.
dc.date.accessioned2024-09-18T20:53:04Z
dc.date.available2024-09-18T20:53:04Z
dc.date.issued2011
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe expression of p16 as a tumor suppressor protein was evaluated in a retrospective analysis of paraffin-embedded tissue specimens of leiomyosarcoma (LMS), leiomyoma (LM) and normal myometrium. In this study, we investigated by immunohistochemistry p16 expression in 15 LMSs, 15 LMs and ten normal myometrium. Strong expression of p16 was found in 12 of the 15 LMSs and in three cases weak expression; three LMs had focal and weak p16 staining but none of the normal myometrium. A statistically significant difference regarding the frequency of p16 protein expression was observed between LMS and LM (p: 0.0001). We concluded that the results of this study confirm the overexpression of p16 in LMS. Therefore, the present study suggests that p16 might be a useful immunohistochemical marker which could help in distinguishing uterine LMS from LM and its benign variants.en_US
dc.identifier.endpage515en_US
dc.identifier.issn0392-2936
dc.identifier.issue5en_US
dc.identifier.pmid22053664en_US
dc.identifier.scopus2-s2.0-81255198835en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage513en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11561
dc.identifier.volume32en_US
dc.identifier.wosWOS:000295668500010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherI R O G Canada, Incen_US
dc.relation.ispartofEuropean Journal of Gynaecological Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectp16 expressionen_US
dc.subjectUterusen_US
dc.subjectLeiomyomaen_US
dc.subjectLeiomyosarcomaen_US
dc.titleImmunohistochemical analysis of p16 expression in uterine smooth muscle tumorsen_US
dc.typeArticleen_US

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