Antimicrobial properties of bioactive compounds isolated from epidermal mucus in two Ray species (Dasyatis marmorata and Gymnura altavela)

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dc.authoridUyan, Ali/0000-0001-9308-3324
dc.contributor.authorUyan, Ali
dc.contributor.authorTuran, Cemal
dc.contributor.authorErdogan-Eliuz, Elif Ayse
dc.contributor.authorSangun, Mustafa Kemal
dc.date.accessioned2024-09-18T20:25:09Z
dc.date.available2024-09-18T20:25:09Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose: To investigate the occurrence and antimicrobial effects of certain biochemical compounds in the epidermal mucus secretions of fish and to demonstrate their potential for biomedical applications. Methods: Crude, aqueous, and acidic epidermal mucus samples were collected from live ray specimens. Gas chromatography and gas chromatography-mass spectrometry (GC/MS) analyses were performed to identify the biochemical compounds present in the mucus. The spectrophotometric broth microdllution method was used to determine the antibacterial and antifungal properties of the mucus extracts. The bacterial strains, Bacillus subtilis, Escherichia coli, Enterococcus faecalis, and Klebsiella pneumonia, were used for the tests, as well as the fungal strains, Candida parapsilosis and Candida albicans. Results: GC/MS analysis revealed the presence of several hydrocarbon-derived compounds in the epidermal mucus of the two ray species. The acidic extract of G. altavela epidermal mucus produced a high MIC value, indicating the highest inhibitory effect of 8.64 mu L against E. coli, while the crude extract of G. altavela epidermal mucus (41.13 mu L against B. subtilis) was the least effective. Conclusion: Epidermal mucus extracts, especially when acid-based, displays strong antimicrobial properties against all the tested pathogens. These findings suggest the plants possess some potential for the development of novel antimicrobial components for applications in medicine.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey [TUBITAK-2211/C]en_US
dc.description.sponsorshipThis study was derived from A Uyan's PhD Thesis. Thanks go to the Scientific and Technological Research Council of Turkey (no. TUBITAK-2211/C National Ph.D. Scholarship Program for Priority Areas) for support.en_US
dc.identifier.doi10.4314/tjpr.v19i10.15
dc.identifier.endpage2121en_US
dc.identifier.issn1596-5996
dc.identifier.issue10en_US
dc.identifier.scopus2-s2.0-85095744022en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage2115en_US
dc.identifier.urihttps://doi.org/10.4314/tjpr.v19i10.15
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10103
dc.identifier.volume19en_US
dc.identifier.wosWOS:000585079600015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPharmacotherapy Groupen_US
dc.relation.ispartofTropical Journal of Pharmaceutical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFishen_US
dc.subjectRay speciesen_US
dc.subjectEpidermal mucusen_US
dc.subjectAntimicrobial propertiesen_US
dc.subjectBioactive compoundsen_US
dc.titleAntimicrobial properties of bioactive compounds isolated from epidermal mucus in two Ray species (Dasyatis marmorata and Gymnura altavela)en_US
dc.typeArticleen_US

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