Tyrosol prevents AlCl3 induced male reproductive damage by suppressing apoptosis and activating the Nrf-2/HO-1 pathway

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dc.authoridGOKCEK, ISHAK/0000-0002-0590-6405
dc.authoridTekeli, Ibrahim Ozan/0000-0002-6845-2279
dc.authoridGUVENC, MEHMET/0000-0002-9716-0697
dc.contributor.authorGuvenc, Mehmet
dc.contributor.authorCellat, Mustafa
dc.contributor.authorGokcek, Ishak
dc.contributor.authorArkali, Gozde
dc.contributor.authorUyar, Ahmet
dc.contributor.authorTekeli, Ibrahim Ozan
dc.contributor.authorYavas, Ilker
dc.date.accessioned2024-09-18T19:54:15Z
dc.date.available2024-09-18T19:54:15Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAluminium is a ubiquitous element that occurs naturally in the soil making human exposure to it is unavoidable. Tyrosol is present in olive oil and is known to have antioxidant effects. Therefore, the present study explores the toxic effects of aluminium chloride (AlCl3) and evaluates the possible protection by tyrosol in male rats. Testicular injury was induced by the administration of AlCl3 (34 mg kg(-1) day(-1)). Rats were treated with either tyrosol (20 mg kg(-1) day(-1)) or AlCl3 (34 mg kg(-1) day(-1)). The experiment lasted for 10 weeks. Biochemical, histopathological and protein expression profiles were determined to decipher the role of tyrosol in protecting the cellular damage. Further, histomorphometric analyses of testes showed deranged architecture along with other noted abnormalities. AlCl3 group rats' testes showed decreased GSH levels, CAT activities, Nrf-2, HO-1, bcl-2 expressions and sperm motility whereas increased caspase-3 expressions, MDA levels, abnormal and dead/live sperm ratio. However, tyrosol treatment attenuated these changes. The present results demonstrate the beneficial role of tyrosol treatment in AlCl3 induced testicular toxicity alterations of rat.en_US
dc.description.sponsorshipMustafa Kemal Universitesi [18. M.043]en_US
dc.description.sponsorshipMustafa Kemal Universitesi, Grant/Award Number: 18. M.043en_US
dc.identifier.doi10.1111/and.13499
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue2en_US
dc.identifier.pmid31828839en_US
dc.identifier.scopus2-s2.0-85076364834en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1111/and.13499
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7588
dc.identifier.volume52en_US
dc.identifier.wosWOS:000502162500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectaluminium chlorideen_US
dc.subjectantioxidanten_US
dc.subjectapoptosis and sperm qualityen_US
dc.subjecttyrosolen_US
dc.titleTyrosol prevents AlCl3 induced male reproductive damage by suppressing apoptosis and activating the Nrf-2/HO-1 pathwayen_US
dc.typeArticleen_US

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