Estimation of periostin as a biomarker for early pregnancy diagnosis in goats: a preliminary study

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dc.contributor.authorKose, A. M.
dc.contributor.authorSaribay, M. K.
dc.contributor.authorUrer, Koldas E.
dc.contributor.authorNaseer, Z.
dc.contributor.authorDogruer, G.
dc.contributor.authorKaraca, F.
dc.contributor.authorCetin, Coskun N.
dc.date.accessioned2024-09-18T20:04:29Z
dc.date.available2024-09-18T20:04:29Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: Periostin (POSTN) is an extracellular matrix (ECM) protein that plays an important role in the metastatic process and cancer cell migration. As implantation is a similar mechanism to metastasis, it has been hypothesized that POSTN may also play a role in the implantation process. Aims: The aim of the present study was to compare POSTN and progesterone levels during the early pregnancy stage in Damascus goats. Methods: Forty goats were synchronized using progesterone based sponges and were mated upon estrus signs display. While ten goats were kept as control (CON) and were not allowed to mate. Blood samples were taken through jugular venepuncture from CON and synchronized goats on day 13, 15, 17, 19, and 21 of breeding. Progesterone and POSTN levels were determined by enzyme-linked immunosorbent assay (ELISA). Later the pregnancy diagnosis was confirmed by transabdominal ultrasonography on day 50 after mating. Results: Progesterone level was influenced by status of pregnancy and day of observation with an interaction between the status of pregnancy and day of observation in goats. Whereas POSTN level was only affected by the day of observation. Conclusion: POSTN level did not vary with progesterone level during phase of embryonic implantation in goats; however, standardization and application of different procedures for POSTN assay in a large group of animals might be useful as an early pregnancy biomarker in goats.en_US
dc.description.sponsorshipMustafa Kemal University Scientific Research Committee [16740]en_US
dc.description.sponsorshipThis study was funded by Mustafa Kemal University Scientific Research Committee by the Project number of 16740.en_US
dc.identifier.doi10.22099/ijvr.2020.38499.5606
dc.identifier.endpage75en_US
dc.identifier.issn1728-1997
dc.identifier.issue1en_US
dc.identifier.pmid34149859en_US
dc.identifier.scopus2-s2.0-85106531301en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage72en_US
dc.identifier.urihttps://doi.org/10.22099/ijvr.2020.38499.5606
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8206
dc.identifier.volume22en_US
dc.identifier.wosWOS:000646204900010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherShiraz Univen_US
dc.relation.ispartofIranian Journal of Veterinary Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiomarkeren_US
dc.subjectGoaten_US
dc.subjectPeriostinen_US
dc.subjectPregnancyen_US
dc.subjectProgesteroneen_US
dc.titleEstimation of periostin as a biomarker for early pregnancy diagnosis in goats: a preliminary studyen_US
dc.typeArticleen_US

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