Ameliorating effect of quercetin on acute pentylenetetrazole induced seizures in rats

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dc.authoridDokuyucu, Recep/0000-0001-6837-3477
dc.authoridDokuyucu, Recep/0000-0001-7881-8871
dc.authoridSefil, Fatih/0000-0001-5534-7448
dc.contributor.authorSefil, Fatih
dc.contributor.authorKahraman, Ibrahim
dc.contributor.authorDokuyucu, Recep
dc.contributor.authorGokce, Hasan
dc.contributor.authorOzturk, Atakan
dc.contributor.authorTutuk, Okan
dc.contributor.authorAydin, Mehmet
dc.date.accessioned2024-09-18T20:19:48Z
dc.date.available2024-09-18T20:19:48Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: The aim of the study to elicit effects of pure quercetin in pentylenetetrazole (PTZ) and picrotoxin induced seizures. Materials and methods: Each animal group was divided into six groups and composed of six rats. Rats were assigned to the following experiments and groups (G): (G1) PTZ 45 mg/kg + DMSO; (G2) PTZ 45 mg/kg + 5 mg/kg quercetin; (G3) PTZ 45 mg/kg + 10 mg/kg quercetin; (G4) PTZ 45 mg/kg + 20 mg/kg quercetin; (G5) PTZ 45 mg/kg + 40 mg/kg quercetin; (G6) Picrotoxin 5 mg/kg + DMSO; (G7) Picrotoxin 5 mg/kg + 10 mg/kg quercetin; (G8) Picrotoxin 5 mg/kg + 20 mg/kg quercetin. In all groups quercetin were injected 30 min before PTZ and picrotoxin applications. Results: Compared to PTZ, quercetin significantly prolonged onset of the seizure in 10 mg/kg (P < 0.05) and reduced the seizure stage in 10 mg/kg quercetin injected group (P < 0.01). Compared to PTZ, quercetin also declined the generalized seizure duration at 10 mg/kg (P < 0.01) and 20 mg/kg (P < 0.05) doses. At the doses of 5 mg/kg and 40 mg/kg quercetin there were no significant changes in seizure parameters. Development of picrotoxin induced seizures is slower than in PTZ. Quercetin was found to be unable to prevent seizure in picrotoxin induced seizures. Surprisingly, quercetin also significantly reduced the onset of seizures at the dose of 20 mg/kg (P < 0.05). Conclusion: quercetin (at doses of 10 and 20 mg/kg i.p) prevented seizures in PTZ (45 mg/kg i.p) induced seizures. Especially, 10 mg/kg PTZ prolonged onset of seizures, reduced the seizure duration and seizure severity score in comparison with control group. At a higher (40 mg/kg) dose quercetin failed to prevent PTZ induced seizures. In addition 20 mg/kg quercetin significantly reduced the onset of seizures that suggest a preconvulsive effect. 20 mg/kg quercetin reduced the onset of picrotoxin induced seizures. In picrotoxin model, it may be claimed that quercetin at higher doses accelerate the epileptic activity owing to its antagonistic effect on GABAA. Further investigations are needed to explore the mechanisms of the antiepileptic and preconvulsant effects of quercetin.en_US
dc.description.sponsorshipMustafa Kemal University Research Foundation [8500-2013]en_US
dc.description.sponsorshipThis project was supported by the Mustafa Kemal University Research Foundation (8500-2013).en_US
dc.identifier.endpage2477en_US
dc.identifier.issn1940-5901
dc.identifier.issue9en_US
dc.identifier.pmid25356099en_US
dc.identifier.scopus2-s2.0-84907856071en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage2471en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9862
dc.identifier.volume7en_US
dc.identifier.wosWOS:000345121000008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofInternational Journal of Clinical and Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEpileptic seizureen_US
dc.subjectpentylenetetrazoleen_US
dc.subjectpicrotoxinen_US
dc.subjectquercetinen_US
dc.subjectflavonoidsen_US
dc.titleAmeliorating effect of quercetin on acute pentylenetetrazole induced seizures in ratsen_US
dc.typeArticleen_US

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