Protective Effect of Nigella Sativa in an Animal Model of Colon Anastomosis With Ischemia/Reperfusion Injury

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dc.authoridAziret, Mehmet/0000-0001-6758-7289
dc.contributor.authorBali, Ilhan
dc.contributor.authorPolat, Fatin Rustu
dc.contributor.authorAziret, Mehmet
dc.contributor.authorSozen, Selim
dc.contributor.authorOruc, Cem
dc.contributor.authorCoskunkan, Ufuk
dc.contributor.authorEmir, Seyfi
dc.date.accessioned2024-09-18T19:54:18Z
dc.date.available2024-09-18T19:54:18Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: Anastomotic leaks are one of the chief complications after gastrointestinal surgery. The aim of this study was to evaluate whether Nigella sativa administration protects against ischemia/reperfusion injury on healing of colonic anastomosis in rats. Method: Thirty male Wistar albino rats, weighing between 200 and 240 g, were used in the study. They were randomly divided into three groups (n = 10 for each group): Anastomosis (group 1), anastomosis and ischemia/reperfusion injury (group 2), and treatment group of anastomosis, ischemia/reperfusion injury, and Nigella sativa (group 3). After 7 days, serum, plasma, and colonic tissue were obtained and then all rats were sacrificed. Tissue and serum level of total oxidant status, total antioxidant status, total thiol levels, hydroxyproline, interleukin-6, and TNF-alpha were determined and specimens were histopathologically evaluated. Results: In the Nigella sativa treated rats, serum hydroxyproline levels were significantly higher, while tissue levels were significantly lower than those seen in group 1 and group 2 (P = 0.007, P = 0.01, respectively). In the Nigella sativa group, the serum levels of TNF-alpha were significantly lower than those seen in group 1 and 2 (P = 0.001). Also, in group 3, the tissue IL-6 level was significantly higher than that seen in group 1 and group 2 (P = 0.009). The histopathologic analysis showed less edema and inflammatory cell infiltration in the Nigella sativa treated group, as well as a statistically significant difference according to the Chiu classification (P < 0.05). Conclusion: The results of this study indicate that Nigella sativa has a protective and therapeutic effect against ischemia/reperfusion injury on the healing of colonic anastomosis in rats.en_US
dc.identifier.doi10.9738/INTSURG-D-15-00301.1
dc.identifier.endpage148en_US
dc.identifier.issn0020-8868
dc.identifier.issue3-4en_US
dc.identifier.scopus2-s2.0-85069832347en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage139en_US
dc.identifier.urihttps://doi.org/10.9738/INTSURG-D-15-00301.1
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7644
dc.identifier.volume103en_US
dc.identifier.wosWOS:000474607300004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherInt College Of Surgeonsen_US
dc.relation.ispartofInternational Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnastomosisen_US
dc.subjectAnastomotic leaksen_US
dc.subjectNigella sativaen_US
dc.subjectIschemia/reperfusion injuryen_US
dc.titleProtective Effect of Nigella Sativa in an Animal Model of Colon Anastomosis With Ischemia/Reperfusion Injuryen_US
dc.typeArticleen_US

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