Effects of nigella sativa l.’s essential oils on multi drug resistant escherichia coli isolates

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dc.authorscopusid35612683100
dc.authorscopusid57196342765
dc.authorscopusid52663095800
dc.authorscopusid57223861926
dc.authorscopusid7004487734
dc.contributor.authorDuran, Nizami
dc.contributor.authorAy, Emrah
dc.contributor.authorBayraktar, Suphi
dc.contributor.authorÇolak, Sezin
dc.contributor.authorKaya, Durmuş Alpaslan
dc.date.accessioned2024-09-19T15:47:05Z
dc.date.available2024-09-19T15:47:05Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractEscherichia coli is one of the most important human pathogens and is a major cause of nosocomial infections. In this study, it was aimed to investigate the antimicrobial efficacy of Nigella sativa L. against multi drug-resistant E. coli isolates. This study was carried out on multi drug resistant E. coli isolates. In this study, seeds of Nigella sativa L. obtained from spice market were used as material.Multidrug resistant E. coli strains were identified by conventional methods. The antibacterial activity of Nigella sativa L.’s essential oils was performed by disk diffusion test. In addition, when needed, automated systems were used for rapid identification of microorganisms and susceptibility testing identification. The ESBL production of these strains was confirmed by double disc synergy test.In ESBL producing E.coli strains, the MIC range of ampicillin was 4-32 ?g/ml and the MIC range of cefuroxime was found to be 2-16 ?g/ ml. MIC values of ampicillin were range from 0.25 to 4 ?g/ml and MIC of levofloxacin range were 1 to 8 ?g/ml and MIC of cefuroxime range were found to be 0.25-4 ?g/ml. Following treatment with essential oils of Nigella sativa, resistance rates of GSBL producing E.coli strains against all these three antibiotics (ampicillin, levofloxacin and cefuroxime) have been found to decrease statistically significantly (p<0.05). Nigella sativa L.’s essential oils showed complete zone of inhibition of the standart E.coli strains (p<0.05). Besides this, in experiments with multi drug resistant E.coli isolates, it was found that the inhibition zones of Nigella-treated GSBL producing E.coli strains differed from non-treated strains. There was a statistically significant increasing in inhibition zones in drug E.coli isolates (p<0.01).The essential oils of Nigella sativa L. may contain promising antimicrobial components in the treatment of multi drug-resistant Ecoli isolates. This is very important for the discovery of new antimicrobial agents. More extensive clinical trials should be undertaken in this regard. © 2018, Bulgarian Society for Microbiology (Union of Scientists in Bulgaria). All rights reserved.en_US
dc.identifier.endpage36en_US
dc.identifier.issn0204-8809
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85105242816en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage32en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14963
dc.identifier.volume34en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBulgarian Society for Microbiology (Union of Scientists in Bulgaria)en_US
dc.relation.ispartofActa Microbiologica Bulgaricaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDrugen_US
dc.subjectEscherichia colien_US
dc.subjectEssential oilen_US
dc.subjectNigella sativa Len_US
dc.subjectResistanceen_US
dc.titleEffects of nigella sativa l.’s essential oils on multi drug resistant escherichia coli isolatesen_US
dc.typeArticleen_US

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