The relationship between vitamin D and disease activity and functional health status in rheumatoid arthritis

Basit Öğe Kaydı
dc.authoridYonden, Zafer/0000-0003-0708-5417
dc.contributor.authorTurhanoglu, Ayse Dicle
dc.contributor.authorGuler, Hayal
dc.contributor.authorYonden, Zafer
dc.contributor.authorAslan, Fatma
dc.contributor.authorMansuroglu, Ayhan
dc.contributor.authorOzer, Cahit
dc.date.accessioned2024-09-18T20:55:48Z
dc.date.available2024-09-18T20:55:48Z
dc.date.issued2011
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractWe aimed to establish the relationship between serum vitamin D levels and disease activity and health status in rheumatoid arthritis. Sixty-five patients with RA fulfilling ACR criteria for the classification of rheumatoid arthritis and forty healthy controls were included in this study. Disease activity was assessed according to the Disease Activity Score including 28 joint counts. C-reactive protein (CRP, mg/dl) was determined by the nephelometric method. Erythrocyte sedimentation rate (ESR, mm/h) was determined by the Westergren method. Rheumatoid factor (RF, IU/ml) was also determined by the nephelometric method, and RF > 20 IU/ml was defined as positive. 25-OH Vitamin D EIA Kit was used to measure serum 25-OH Vitamin D levels. We found that the mean of the 25-OH D vitamin levels of the patients with RA was not different than that of controls (P = 0.936). We divided patients with RA into three groups according to DAS28 as low activity group (group 1, n = 25), moderate activity group (group 2, n = 25), and high activity group (group 3, n = 15). 25-OH vitamin D levels of the patients in the high activity group (group 3) were found to be the lowest (P < 0.001), and the patients with moderate disease activity had lower levels than those in the mild group (P = 0.033). Serum 25-OH vitamin D levels were significantly negatively correlated with DAS28, CRP, and HAQ (respectively, r = -0.431, P = 0.000, r = -0.276, P = 0.026, and r = -0.267, P = 0.031). Serum vitamin D levels in patients with RA were similar those in the healthy controls, while it significantly decreases in accordance with the disease activity and decreasing functional capacity.en_US
dc.identifier.doi10.1007/s00296-010-1393-6
dc.identifier.endpage914en_US
dc.identifier.issn0172-8172
dc.identifier.issn1437-160X
dc.identifier.issue7en_US
dc.identifier.pmid20300755en_US
dc.identifier.scopus2-s2.0-85027951007en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage911en_US
dc.identifier.urihttps://doi.org/10.1007/s00296-010-1393-6
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12054
dc.identifier.volume31en_US
dc.identifier.wosWOS:000291986900011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofRheumatology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRheumatoid Arthritisen_US
dc.subjectDisease activityen_US
dc.subjectVitamin Den_US
dc.titleThe relationship between vitamin D and disease activity and functional health status in rheumatoid arthritisen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ N/A ]
İsim:
Tam Metin / Full Text
Boyut:
224.56 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu