CHANGES IN TRYPTASE LEVELS DURING CARDIAC SURGERY IN PATIENTS AT LOW RISK FOR ALLERGIC REACTIONS

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dc.authoridozcan, oguzhan/0000-0001-7486-503X
dc.authoridARDICOGLU AKISIN, N. YASEMIN/0000-0002-4109-0220
dc.contributor.authorOksar, Menekse
dc.contributor.authorBaytan, Hasibe G.
dc.contributor.authorTurhanoglu, Selim
dc.contributor.authorAybek, Tayfun
dc.contributor.authorArdicoglu, Nazife Y.
dc.contributor.authorOzcan, Oguzhan
dc.date.accessioned2024-09-18T20:27:55Z
dc.date.available2024-09-18T20:27:55Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractTryptase test can be used as a clinical marker of mast cell activation. The present study is was aimed to identify variations in serum tryptase levels and their possible relationships with allergic reactions to protamine in low-risk patients undergoing cardiac bypass surgery. Thirty patients according to American Society of Anesthesiologists physical status III who underwent cardiac bypass surgery were enrolled. This prospective, non-randomised, clinical study was conducted in an operating room. Venous blood samples for tryptase measurements were obtained from cardiac bypass surgery patients upon admission to the operating room and immediately before and 30 min after the initiation of protamine administration. Signs of allergic reactions were recorded and management steps based on rapid effect response-based clinical assessments for diagnosis and treatment decisions during protamine administrations were described. Serum tryptase levels and clinical signs of allergic reactions, primarily mean arterial pressure (MAP), were recorded. Serum tryptase levels increased significantly and progressively during the bypass procedure (study power, 80%; sample size, 28; power of analysis, 99.8% with alpha=0.05); however, tryptase levels did not reach a sufficiently high level to confirm an allergic reaction. The MAP and heart rate decreased in 50% of the patients. Although tryptase increased significantly when compared with baseline levels, protamine-associated increases were not significant and failed to provide an unequivocal indication of an allergic response to protamine.en_US
dc.description.sponsorshipinstitutional fund of Hatay Mustafa Kemal University, Turkey [12200]en_US
dc.description.sponsorshipThe study (study code: 12200) was supported by the institutional fund of Hatay Mustafa Kemal University, Turkey.en_US
dc.identifier.doi10.26641/2307-0404.2022.4.271173
dc.identifier.endpage73en_US
dc.identifier.issn2307-0404
dc.identifier.issn2786-4804
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85147648495en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage65en_US
dc.identifier.urihttps://doi.org/10.26641/2307-0404.2022.4.271173
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10606
dc.identifier.volume27en_US
dc.identifier.wosWOS:000911450700009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherDnipro State Medical Univen_US
dc.relation.ispartofMedicni Perspektivien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecthypersensitivityen_US
dc.subjectanaesthesiaen_US
dc.subjectcardiac proceduresen_US
dc.subjectprotaminesen_US
dc.subjectadverse effectsen_US
dc.subjecttryptasesen_US
dc.titleCHANGES IN TRYPTASE LEVELS DURING CARDIAC SURGERY IN PATIENTS AT LOW RISK FOR ALLERGIC REACTIONSen_US
dc.typeArticleen_US

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