Conjunctival Histopathological Changes in Children With Vitamin D Deficiency

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dc.contributor.authorAydemir, Gozde Aksoy
dc.contributor.authorIlhan, Cagri
dc.contributor.authorPehlivanoglu, Burcin
dc.contributor.authorAydemir, Emre
dc.contributor.authorKiziltoprak, Hasan
dc.contributor.authorBolu, Semih
dc.date.accessioned2024-09-18T20:27:58Z
dc.date.available2024-09-18T20:27:58Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose: The aim of this study was to investigate tear function-associated clinical findings and conjunctival histopathological changes in children with vitamin D (Vit-D) deficiency. Methods: This study used a prospective case-control design. Group 1 (n=38) comprised pediatric patients with Vit-D deficiency, and group 2 (n=45) was the control group. Tear break-up times (TBUTs), Schirmer-1 test measurements, ocular surface disease index (OSDI) scores, and conjunctival impression cytology (CIC) results of the groups were compared. Results: The participant demographic characteristics, including the mean age and the male-to-female ratio, were similar (P>0.05). The median TBUT and Schirmer-1 test measurement were 10 s (5-15) and 12 mm (6-19) in group 1 and 11 s (6-16) and 15 mm (8-21) in group 2 (P=0.004 and P=0.013, respectively). The median OSDI scores were 16 (10-20) in group 1 and 17 (10-21) in group 2 (P=0.092). According to the CIC, 25 samples in group 1 and 40 samples in group 2 were categorized as grade 0, 11 samples in group 1 and 5 samples in group 2 were categorized as grade 1, and 2 samples in group 1 and no sample in group 2 were categorized as grade 2 (P=0.027). Conclusion: Significant conjunctival histopathological changes occur in children with Vit-D deficiency, and these changes have effects on some tear function-associated clinical findings including the Schirmer-1 test and TBUT measurements.en_US
dc.identifier.doi10.1097/ICL.0000000000000903
dc.identifier.endpage294en_US
dc.identifier.issn1542-2321
dc.identifier.issn1542-233X
dc.identifier.issue7en_US
dc.identifier.pmid35580362en_US
dc.identifier.startpage289en_US
dc.identifier.urihttps://doi.org/10.1097/ICL.0000000000000903
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10642
dc.identifier.volume48en_US
dc.identifier.wosWOS:000813774900004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofEye & Contact Lens-Science and Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectImpression cytologyen_US
dc.subjectSchirmeren_US
dc.subjectTear break-up timeen_US
dc.subjectVitamin Den_US
dc.titleConjunctival Histopathological Changes in Children With Vitamin D Deficiencyen_US
dc.typeArticleen_US

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