Seizures with pentylenetetrazol kindling cause a decrease in the number of pyramidal neurons in the rat hippocampus

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dc.authorscopusid57192891758
dc.authorscopusid23994048900
dc.authorscopusid56798472700
dc.authorscopusid15063935100
dc.authorscopusid56814477900
dc.authorscopusid6603762396
dc.authorscopusid6701737157
dc.contributor.authorKocacan, Süleyman Emre
dc.contributor.authorSefil, Fatih
dc.contributor.authorElibol, Ebru
dc.contributor.authorAltunkaynak, Berrin Z.
dc.contributor.authorAcar, Meryem Dilek
dc.contributor.authorBağirici, Faruk
dc.contributor.authorMarangoz, Cafer
dc.date.accessioned2024-09-19T15:45:41Z
dc.date.available2024-09-19T15:45:41Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractOBJECTIVE: To investigate the effects of pentylenetetrazole (PTZ) kindling on the number of pyramidal neurons in the rat hippocampus. STUDY DESIGN: Using unbiased stereology, we calculated total pyramidal neuron numbers in the CA1, CA2, and CA3 areas and the whole hippocampus after PTZ-induced kindling. The estimation and the analysis of the number of hippocampal pyramidal cells (areas of CA1-3) were done with the optical fractionator technique, which is a stereological counting technique. RESULTS: Stereological analysis showed that the total number of pyramidal neurons in the whole hippocampus and the number of pyramidal neurons in CA1 were significantly lower in kindled rats as compared to the controls (p < 0.05). However, no significant difference was found in the neuron numbers of CA2 and CA3 (p>0.05). CONCLUSION: PTZ-induced seizures cause a decrease in the amount of pyramidal neurons in the CA area of the rat hippocampus. © Science Printers and Publishers, Inc.en_US
dc.identifier.endpage300en_US
dc.identifier.issn2578-742X
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85008684365en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage295en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14834
dc.identifier.volume38en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherScience Printers and Publishers Inc.en_US
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectConvulsantsen_US
dc.subjectEpilepsyen_US
dc.subjectKindling, neurologicen_US
dc.subjectNeurological disordersen_US
dc.subjectNeurotoxicityen_US
dc.subjectNeurotoxicity syndromesen_US
dc.subjectNeurotoxin diseasesen_US
dc.subjectPentylenetetrazoleen_US
dc.subjectSeizuresen_US
dc.subjectStereologyen_US
dc.titleSeizures with pentylenetetrazol kindling cause a decrease in the number of pyramidal neurons in the rat hippocampusen_US
dc.typeArticleen_US

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