Determination of Serum Oxidative Stress, Antioxidant Capacity and Protein Profiles in Dogs Naturally Infected with Ehrlichia canis

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dc.authorscopusid15755525400
dc.authorscopusid23493462500
dc.authorscopusid15831622800
dc.authorscopusid23396243700
dc.authorscopusid56045626500
dc.authorscopusid26532288600
dc.authorscopusid57190279076
dc.contributor.authorÇiftci, Gülay
dc.contributor.authorPekmezci, Didem
dc.contributor.authorGüzel, Murat
dc.contributor.authorÇenesiz, Sena
dc.contributor.authorUral, Kerem
dc.contributor.authorAysul, Nuran
dc.contributor.authorKazak, Filiz
dc.date.accessioned2024-09-19T15:43:34Z
dc.date.available2024-09-19T15:43:34Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose: Canine ehrlichiosis is an important tick-borne disease of dogs worldwide. In the present study, we aimed to determine the serum total antioxidant capacity (TAC), malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase, (SOD), glutathione peroxidase (GSH-Px), adenosine deaminase (ADA) activity and serum protein profiles in dogs affected with naturally acquired ehrlichiosis. Methods: The animal materials had been consisted of ten dogs naturally infected with Ehrlichia canis, and ten controls negative for Ehrlichia canis. TAC, MDA, NO, SOD, GSH-Px, ADA activity and TP, ALB, GLOB levels were measured in sera of the animals. The serum protein concentrations were measured by autoanalyzer. The electrophoretic profiles of serum total protein were determined by native polyacrylamide gel electrophoresis (Native-PAGE). Results: In dogs with ehrlichiosis, decreased TAC (P < 0.05) and GSH-Px (P > 0.05) levels were determined. However, NO (P > 0.05), SOD (P < 0.05), ADA (P > 0.05), MDA (P > 0.05), TP (P < 0.05) and GLO (P < 0.05) levels were found as increased in the Ehrlichia positive dogs. ALB levels were decreased without a statistical significance (P > 0.05). ALB, ?1 and ?2 globulin strip densities were found as decreased in native-PAGE, while ?1 and ? globulin strip densities were significantly increased in the E. canis positive group when compared to the control. Conclusion: It was determined that the oxidative stress decreased high antioxidant activity in dogs naturally infected with E. canis, and consequently, pro-oxidant and antioxidant defense and serum protein profiles were affected. It was thought that antioxidant supplementation could be beneficial to the treatment of the disease. © 2021, Witold Stefa?ski Institute of Parasitology, Polish Academy of Sciences.en_US
dc.identifier.doi10.1007/s11686-021-00411-6
dc.identifier.endpage1348en_US
dc.identifier.issn1230-2821
dc.identifier.issue4en_US
dc.identifier.pmid34018150en_US
dc.identifier.scopus2-s2.0-85106258739en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1341en_US
dc.identifier.urihttps://doi.org/10.1007/s11686-021-00411-6
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14425
dc.identifier.volume66en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Science and Business Media Deutschland GmbHen_US
dc.relation.ispartofActa Parasitologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidanten_US
dc.subjectEhrlichia canisen_US
dc.subjectOxidant<sup>.</sup>en_US
dc.subjectSerum protein levelsen_US
dc.titleDetermination of Serum Oxidative Stress, Antioxidant Capacity and Protein Profiles in Dogs Naturally Infected with Ehrlichia canisen_US
dc.typeArticleen_US

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