Oxidative Status in Epileptic Children Using Carbamazepine

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dc.authoridDokuyucu, Recep/0000-0001-7881-8871
dc.authoridDokuyucu, Recep/0000-0001-6837-3477
dc.contributor.authorTutanc, Murat
dc.contributor.authorAras, Mustafa
dc.contributor.authorDokuyucu, Recep
dc.contributor.authorAltas, Murat
dc.contributor.authorZeren, Cem
dc.contributor.authorArica, Vefik
dc.contributor.authorOzturk, Oktay Hasan
dc.date.accessioned2024-09-18T20:06:28Z
dc.date.available2024-09-18T20:06:28Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: There is an increasing attention towards the relationship between oxidative stress and epilepsy. The effect of antiepileptic drugs on oxidant status is of major interest. Antiepileptic drugs can increase levels of free radicals, which consequently might lead to seizures. Carbamazepine (CBZ) is an antiepileptic drug commonly used in childhood and adolescence. Objectives: Therefore we aimed to investigate the effects of CBZ on total antioxidant status, total oxidant stress, and oxidative stress index. Patients and Methods: The study included 40 epileptic patients and 31 healthy children between 4 and 12 years of age. Serum CBZ level, total antioxidant capacity and total oxidant status were measured. Oxidative stress index was also calculated both in controls and patients. Results: In the epileptic group, decreased levels of total antioxidant capacity, increased total oxidative stress and oxidative stress index levels were found. Positive correlation between plasma CBZ levels and total oxidant status was observed. Conclusions: Antioxidant action could not be playing any role in antiepileptic effect of CBZ. Furthermore, increased oxidative stress induced by CBZ could be the cause of CBZ-induced seizures. Therefore combining CBZ with antioxidants could be beneficial.en_US
dc.identifier.doi10.5812/ijp.3885
dc.identifier.issn2008-2142
dc.identifier.issn2008-2150
dc.identifier.issue6en_US
dc.identifier.pmid26635944en_US
dc.identifier.scopus2-s2.0-84981747402en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.5812/ijp.3885
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8538
dc.identifier.volume25en_US
dc.identifier.wosWOS:000369891100010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBrieflanden_US
dc.relation.ispartofIranian Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCarbamazepineen_US
dc.subjectAntioxidant Capacityen_US
dc.subjectOxidant Statusen_US
dc.titleOxidative Status in Epileptic Children Using Carbamazepineen_US
dc.typeArticleen_US

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